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Gender-Linked Stem Cell Alterations in Stroke and Postpartum Depression.
Abstract Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a comorbidity factor of stroke, plays a key role in regenerative medicine, in particular stem cell therapy. We hypothesize that gender is a key factor in culture-induced stemness of adult stem cells. Our goal is to provide new evidence supporting gender effects on stroke and stem cells for the pur...
Source: CNS Neuroscience and Therapeutics - November 15, 2014 Category: Neuroscience Authors: Pabón MM, Ji XM, Fernandez JW, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke.
CONCLUSIONS: Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation. PMID: 24393245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, Zhuge QC, Xie LK, Wang B, Su DM, Jin KL Tags: CNS Neurosci Ther Source Type: research

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke.
Abstract Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-ba...
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Tang YH, Ma YY, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.
CONCLUSION: These findings highlight the therapeutic effects of EPI-NCSCs transplantation, probably through simultaneous induction of neuronal and glial formation, as well as Bdnf over-expression in a rat model of ischemic stroke. PMID: 32281225 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - April 11, 2020 Category: Neuroscience Authors: Salehi MS, Pandamooz S, Safari A, Jurek B, Tamadon A, Namavar MR, Dianatpour M, Dargahi L, Azarpira N, Fattahi S, Shid Moosavi SM, Keshavarz S, Khodabandeh Z, Zare S, Nazari S, Heidari M, Izadi S, Poursadeghfard M, Borhani-Haghighi A Tags: CNS Neurosci Ther Source Type: research

Hippocampal neuroprotection mediated by secretome of human mesenchymal stem cells against experimental stroke
CONCLUSION: Our results suggest that hESC-MSC-CM could promote neurogenesis and protect brain tissue from ischemic injury, partly mediated by induction of angiogenesis and neurotrophic factors and inhibition of inflammatory and apoptotic factors expression.PMID:35715988 | DOI:10.1111/cns.13886
Source: CNS Neuroscience and Therapeutics - June 18, 2022 Category: Neuroscience Authors: Afsaneh Asgari Taei Leila Dargahi Pariya Khodabakhsh Mehdi Kadivar Maryam Farahmandfar Source Type: research

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation.
CONCLUSION: Our results indicate that PFT-α enhances the survival of grafted NSCs through the inhibition of p53 translocation into the nucleus. PMID: 23253187 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Lei XH, Zhao D, Li YL, Li XF, Sun X, Du WZ, Sun Y, Hao ZF, Xin SY, Liu C, Zhang ZR, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice
CONCLUSION: The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke.PMID:37592866 | DOI:10.1111/cns.14412
Source: CNS Neuroscience and Therapeutics - August 18, 2023 Category: Neuroscience Authors: Yu Yang Qianqian Liu Song Deng Qian Shao Long Peng Yuejuan Ling Yue Huang Siqi Zheng Qiaoji Jiang Dekang Nie Jian Chen Source Type: research

Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury.
Abstract Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death and secondary cell death closely model disease progression and worsen outcomes. Mounting evidence indicates that long-term neuroinflammation extensively exacerbates the secondary deterioration of brain structure and function. Due to their immunomodulatory and regenerative properties, mesenchymal stem cell transplants have emerged as a promising approach to treating this facet of stroke and TBI pathology. In this review, we summ...
Source: CNS Neuroscience and Therapeutics - April 30, 2020 Category: Neuroscience Authors: Bonsack B, Corey S, Shear A, Heyck M, Cozene B, Sadanandan N, Zhang H, Gonzales-Portillo B, Sheyner M, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

MiR-199a-5p enhances neuronal differentiation of neural stem cells and promotes neurogenesis by targeting Cav-1 after cerebral ischemia
CONCLUSION: MiR-199a-5p may target and inhibit Cav-1 to enhance neurogenesis and thus promote functional recovery after cerebral ischemia. These findings indicate that miR-199a-5p is a promising target for the treatment of ischemic stroke.PMID:37349971 | DOI:10.1111/cns.14323
Source: CNS Neuroscience and Therapeutics - June 23, 2023 Category: Neuroscience Authors: Hua-Qian Jin Wei-Feng Jiang Xin-Tian Zheng Lin Li Yan Fang Yan Yang Xiao-Wei Hu Li-Sheng Chu Source Type: research

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