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Prevention of conversion to abnormal tcd with hydroxyurea in sickle cell anemia: A phase III international randomized clinical trial
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - September 28, 2015 Category: Hematology Authors: Jane S. Hankins, M. Beth McCarville, Angela Rankine‐Mullings, Marvin E. Reid, Clarisse L.C. Lobo, Patricia G. Moura, Susanna Ali, Deanne Soares, Karen Aldred, Dennis W. Jay, Banu Aygun, John Bennett, Guolian Kang, Jonathan C. Goldsmith, Matthew P. Smelt Tags: Research Article Source Type: research

Prevention of conversion to abnormal transcranial Doppler with hydroxyurea in sickle cell anemia: A Phase III international randomized clinical trial
Children with sickle cell anemia (SCA) and conditional transcranial Doppler (TCD) ultrasound velocities (170–199 cm/sec) may develop stroke. However, with limited available clinical data, the current standard of care for conditional TCD velocities is observation. The efficacy of hydroxyurea in preventing conversion from conditional to abnormal TCD (≥200 cm/sec), which confers a higher stroke risk, has not been studied prospectively in a randomized trial. Sparing Conversion to Abnormal TCD Elevation (SCATE #NCT01531387) was a National Heart, Lung, and Blood Institute‐funded Phase III multicenter international clinical...
Source: American Journal of Hematology - November 17, 2015 Category: Hematology Authors: Jane S. Hankins, Mary Beth McCarville, Angela Rankine‐Mullings, Marvin E. Reid, Clarisse L.C. Lobo, Patricia G. Moura, Susanna Ali, Deanne P. Soares, Karen Aldred, Dennis W. Jay, Banu Aygun, John Bennett, Guolian Kang, Jonathan C. Goldsmith, Matthew P. Tags: Research Article Source Type: research