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Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
CONCLUSION: Implementation of a unique, jurisdiction-wide PBM program was associated with improved patient outcomes, reduced blood product utilization, and product-related cost savings. PMID: 28150313 [PubMed - as supplied by publisher]
Source: Transfusion - February 1, 2017 Category: Hematology Authors: Leahy MF, Hofmann A, Towler S, Trentino KM, Burrows SA, Swain SG, Hamdorf J, Gallagher T, Koay A, Geelhoed GC, Farmer SL Tags: Transfusion Source Type: research

Successful kidney transplantation in a patient with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome).
CONCLUSION: Our experience suggests that kidney transplantation may be an appropriate management for carefully selected patients with congenital TTP who develop end-stage renal disease. PMID: 28940540 [PubMed - as supplied by publisher]
Source: Transfusion - September 20, 2017 Category: Hematology Authors: Fattah H, Kumar D, George JN, Massey HD, King AL, Friedman KD, Gupta G Tags: Transfusion Source Type: research

Transfusion-transmitted malaria masquerading as sickle cell crisis with multisystem organ failure.
CONCLUSIONS: Clinical suspicion for transfusion-related adverse events, including hemolytic transfusion reactions and transfusion-transmitted infections, should be high in typically and atypically immunocompromised patient populations (like SCD), especially those on chronic transfusion protocols. Manual blood smear review aids in the evaluation of patients with SCD presenting with severe vaso-occlusive crisis and MSOF and can alert clinicians to the need for initiating aggressive therapy like RBC exchange and artesunate therapy. PMID: 29524230 [PubMed - as supplied by publisher]
Source: Transfusion - March 9, 2018 Category: Hematology Authors: Maier CL, Gross PJ, Dean CL, Chonat S, Ip A, McLemore M, El Rassi F, Stowell SR, Josephson CD, Fasano RM Tags: Transfusion Source Type: research

Automated RBC exchange compared to manual exchange transfusion for children with sickle cell disease is cost-effective and reduces iron overload.
CONCLUSION: Erythrocytapheresis reduces iron overload and allows a longer interval between procedures without a higher RBC requirement from the second year on aRBX. The cost did not increase as estimated in our Belgian Health Care System. PMID: 29574950 [PubMed - as supplied by publisher]
Source: Transfusion - March 25, 2018 Category: Hematology Authors: Dedeken L, Lê PQ, Rozen L, El Kenz H, Huybrechts S, Devalck C, Diallo S, Heijmans C, Ferster A Tags: Transfusion Source Type: research

Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing long-term transfusion after prolonged, subhemolytic shear exposure.
CONCLUSION: We found that long-term transfusion therapy normalizes the MS threshold above which RBC subhemolytic damage occurs after prolonged shear exposure in SCD. An important and novel finding in transfused patients with SCD was the improvement in RBC deformability in response to prolonged shear exposure over the physiologic range. PMID: 30325033 [PubMed - as supplied by publisher]
Source: Transfusion - October 16, 2018 Category: Hematology Authors: Simmonds MJ, Suriany S, Ponce D, Detterich JA Tags: Transfusion Source Type: research

A rationale for universal tranexamic acid in major joint arthroplasty: overall efficacy and impact of risk factors for transfusion.
CONCLUSIONS: Universal TXA was associated with a reduction of RBC transfusion, overall and in clinically relevant subgroups, strengthening the rationale for universal therapy. PMID: 30383292 [PubMed - as supplied by publisher]
Source: Transfusion - November 1, 2018 Category: Hematology Authors: Pavenski K, Ward SE, Hare GMT, Freedman J, Pulendrarajah R, Pirani RA, Sheppard N, Vance C, White A, Lo N, Waddell JP, Ho A, Schemitsch EH, Kataoka M, Bogoch ER, Saini K, David Mazer C, Baker JE Tags: Transfusion Source Type: research

Use of intravenous immunoglobulin G to treat spontaneous heparin-induced thrombocytopenia.
CONCLUSION: These results suggest that IVIG may be a useful adjunctive therapy in spontaneous HIT. PMID: 30556588 [PubMed - as supplied by publisher]
Source: Transfusion - December 17, 2018 Category: Hematology Authors: Irani M, Siegal E, Jella A, Aster R, Padmanabhan A Tags: Transfusion Source Type: research

Additional filtering of blood from a cell salvage device is not likely to show important additional benefits in outcome in cardiac surgery.
CONCLUSION: The routine use of an additional filter for transfusion of salvaged blood is unlikely to show important additional benefits. PMID: 30610759 [PubMed - as supplied by publisher]
Source: Transfusion - January 4, 2019 Category: Hematology Authors: de Vries AJ, Vermeijden WJ, van Pelt LJ, van den Heuvel ER, van Oeveren W Tags: Transfusion Source Type: research

Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange.
CONCLUSIONS: Patients exhibiting greater daily HbA decrement were more likely to have multiple emergency department visits or admissions for sickling crises. Modulating HbA decrement may merit study as an intermediate metric for interventions to improve outcomes in hemoglobin SS disease. PMID: 31161685 [PubMed - as supplied by publisher]
Source: Transfusion - June 2, 2019 Category: Hematology Authors: Kamyszek RW, Raval JS, Srinivasan AJ, Ansari AK, Evans BA, Rollins-Raval MA, Poisson JL, Shah NR, Welsby IJ Tags: Transfusion Source Type: research

Safety and benefits of automated red cell reduction-exchange compared to standard exchange in patients with sickle cell disease undergoing chronic transfusion.
CONCLUSIONS: Our study supports that IHD-RCE can be safely used in patients with stroke risk and compared to standard RCE, results in benefits of lower RBC usage and/or fraction of cells remaining and higher postprocedure Hct associated with higher preprocedure Hct. These findings support wider use of IHD-RCE, especially in the current environment with reduced availability of minority units. PMID: 33368343 [PubMed - as supplied by publisher]
Source: Transfusion - December 24, 2020 Category: Hematology Authors: Ziemba Y, Xu C, Fomani KM, Nandi V, Yuan T, Rehmani S, Sachais BS, Appiah-Kubi AO, Aygun B, Louie JE, Shi PA Tags: Transfusion Source Type: research

Hemodilution in high-risk cardiac surgery: Laboratory values, physiological parameters, and outcomes
This study suggests hemodilution to be a safe and comparable blood conservation technique, even without accounting for potential benefits of reduced allogenic blood administration. The study may contribute to better understanding and wider acceptance of ANH protocols in high-risk cardiac surgeries.PMID:35244229 | DOI:10.1111/trf.16844
Source: Transfusion - March 4, 2022 Category: Hematology Authors: Domagoj Mladinov Luz A Padilla Benjamin Leahy Joseph B Norman Jacob Enslin Riley S Camp Kyle W Eudailey Kenichi Tanaka James E Davies Source Type: research

Over-transfusion with blood for suspected hemorrhagic shock is not associated with worse clinical outcomes
DISCUSSION: Early empiric RBC transfusion for presumed hemorrhagic shock may subject patients to potential over-transfusion and end-organ damage. Among patients meeting clinical triggers for MTP, 1-3 units of allogeneic RBCs is not associated with worse outcomes.PMID:35753037 | DOI:10.1111/trf.16978
Source: Transfusion - June 26, 2022 Category: Hematology Authors: Rondi B Gelbard Russell L Griffin Lindy Reynolds Peter Abraham Jeffrey Warner Parker Hu Jeffrey D Kerby Rindi Uhlich Marisa B Marques Jan O Jansen John B Holcomb Source Type: research

Factor eight inhibiting bypass activity for refractory bleeding in acute type A aortic dissection repair: A propensity-matched analysis
We report our experience in utilizing FEIBA in ATAAD repair.STUDY DESIGN AND METHODS: A retrospective review was undertaken of all consecutive patients who underwent repair of ATAAD between July 2014 and December 2019. Patients were divided into two groups, dependent upon whether or not they received FEIBA intraoperatively: "FEIBA" (n = 112) versus "no FEIBA" (n = 119). From this, 53 propensity-matched pairs of patients were analyzed with respect to transfusion requirements and short-term clinical outcomes.RESULTS: Thirty-day mortality for the entire cohort was 11.7% (27 deaths), not significantly different between patient...
Source: Transfusion - September 21, 2022 Category: Hematology Authors: Stevan S Pupovac Randy Levine Ashley T Giammarino Samuel Jacob Scheinerman Alan R Hartman Derek R Brinster Jonathan M Hemli Source Type: research

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