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Glycoprotein V : the unsolved GPV puzzle
Platelets. 2022 Jan 7:1-8. doi: 10.1080/09537104.2021.2022114. Online ahead of print.ABSTRACTGlycoprotein V (GPV) is a highly expressed 82 KDa platelet surface transmembrane protein which is loosely attached to the GPIb-IX complex. Despite remaining questions concerning its function, GPV presents several unique features which have repercussions in hematology, atherothrombosis, immunology and transfusion. GPV is specifically expressed in platelets and megakaryocytes and is an ideal marker and reporter gene for the late stages of megakaryopoiesis. The ectodomain of GPV can be released by a number of proteases, namely thrombi...
Source: Platelets - January 7, 2022 Category: Hematology Authors: Quentin Kimmerlin Sylvie Moog Catherine Ravanat Catherine Strassel Fran çois Lanza Source Type: research

Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy
Platelets. 2022 Feb 2:1-10. doi: 10.1080/09537104.2021.2023735. Online ahead of print.ABSTRACTInterrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or pulmonary embolism. The underlying key receptor distributions and interactions, in particular the relevance of integrin clustering, are not fully understood is because of highly abundant and densely distributed αIIbβ3 receptors. This makes receptor distributions difficult to assess ev...
Source: Platelets - February 3, 2022 Category: Hematology Authors: Hannah S Heil Max Aigner Sophia Maier Prateek Gupta Luise M C Evers Vanessa G öb Charly Kusch Mara Meub Bernhard Nieswandt David Stegner Katrin G Heinze Source Type: research

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