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Crushed/chewed administration of potent P2Y < sub > 12 < /sub > inhibitors in ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: Systematic review and meta-analysis
Platelets. 2021 Sep 2:1-8. doi: 10.1080/09537104.2021.1974370. Online ahead of print.ABSTRACTCrushed or chewed potent P2Y12 inhibitors are commonly used in the hope of bridging the gap of platelet inhibition in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). The study aimed to investigate the efficacy and safety of this alternative oral administration strategy by performing a meta-analysis of available randomized clinical trials (RCTs). PubMed, Embase, the Cochrane Library and Web of Science medical literature databases were searched for RCTs co...
Source: Platelets - September 2, 2021 Category: Hematology Authors: Chen Guo Jin-Rui Zhao Meng-Jie Chen Yue Zhang Rui-Yun Wu Qiang-Qiang Li Hong Zhao Jin Wei Source Type: research

Significance of mild thrombocytopenia in maintenance hemodialysis patients; a retrospective cohort study
Platelets. 2021 Oct 21:1-8. doi: 10.1080/09537104.2021.1983531. Online ahead of print.ABSTRACTPlatelet activation in the hemodialysis (HD) circuit often causes thrombocytopenia. However, its clinical and pathophysiological significance has rarely been explored. Herein, we investigated the predictive value of thrombocytopenia for cardiovascular events (CVE) in maintenance HD patients and attempted to explore its mechanistic background considering recent knowledge of platelet dynamics. We conducted a retrospective cohort study on HD patients with the composite primary endpoint of predicting CVE, i.e., myocardial infarction, ...
Source: Platelets - October 21, 2021 Category: Hematology Authors: Yukiko Toyoda Kaoru Tateno Yorinobu Takeda Yoshio Kobayashi Source Type: research

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