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Specialty: Neuroscience
Source: Neuroscience
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Total 165 results found since Jan 2013.
Disrupted structural and functional connectivity networks in ischemic stroke patients
Publication date: 19 November 2017 Source:Neuroscience, Volume 364 Author(s): Jingna Zhang, Ye Zhang, Li Wang, Linqiong Sang, Jun Yang, Rubing Yan, Pengyue Li, Jian Wang, Mingguo Qiu Local lesions caused by stroke may result in extensive structural and functional reorganization in the brain. Previous studies of this phenomenon have focused on specific brain networks. Here, we aimed to discover abnormalities in whole-brain networks and to explore the decoupling between structural and functional connectivity in patients with stroke. Fifteen ischemic stroke patients and 23 normal controls (NCs) were recruited in this study. ...
Source: Neuroscience - October 11, 2017 Category: Neuroscience Source Type: research
Impaired implicit learning and feedback processing after stroke
Publication date: 9 February 2016 Source:Neuroscience, Volume 314 Author(s): J.M. Lam, C. Globas, J.A. Hosp, H.-O. Karnath, T. Wächter, A.R. Luft The ability to learn is assumed to support successful recovery and rehabilitation therapy after stroke. Hence, learning impairments may reduce the recovery potential. Here, the hypothesis is tested that stroke survivors have deficits in feedback-driven implicit learning. Stroke survivors (n =30) and healthy age-matched control subjects (n =21) learned a probabilistic classification task with brain activation measured using functional magnetic resonance imaging in a subse...
Source: Neuroscience - December 18, 2015 Category: Neuroscience Source Type: research
Effects of unilateral stroke on multi-finger synergies and their feed-forward adjustments
Publication date: 5 April 2016 Source:Neuroscience, Volume 319 Author(s): H.J. Jo, C. Maenza, D.C. Good, X. Huang, J. Park, R.L. Sainburg, M.L. Latash We explored the changes in multi-finger synergies in patients after a single cortical stroke with mild motor impairments. We hypothesized that both synergy indices and anticipatory synergy adjustments prior to the initiation of a self-paced quick action would be diminished in the patients compared to age-matched controls. The patients with history of cortical stroke, and age-matched controls (n =12 in each group) performed one-finger and multi-finger accurate force ...
Source: Neuroscience - February 10, 2016 Category: Neuroscience Source Type: research
Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke
In this study, we have evaluated the impact of these two types of stroke in the cell survival and evolution of stroke, focusing on microglial cells, the first responders to cell injury. Two groups of heterozygote Cx3CR1-GFP reporter mice (to follow microglia) were subject to stroke injury either with coagulator-mediated occlusion or photothrombotic MCA damage. Microglial cells’ dynamics of activation and phagocytosis together with astrocytic response and leukocyte infiltration were characterized at 1, 3 and 7days after damage. Photothrombotic stroke delayed microglial and astrocytic invasion of the ischemic core and accu...
Source: Neuroscience - January 11, 2017 Category: Neuroscience Source Type: research
Age dependent disturbances of neuronal and glial protein expression profiles in areas of secondary neurodegeneration post-stroke
Publication date: Available online 29 July 2018Source: NeuroscienceAuthor(s): Murielle G. Kluge, Kimberley Jones, Lin Kooi Ong, Emma K. Gowing, Michael Nilsson, Andrew N. Clarkson, Frederick R. WalkerAbstractDespite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate about translation and generalisability of these results. We were interested in potential age differences in stroke-induced secondary neurodegeneration (SND). SND involves the death of neurons in areas remote from, but connected to, the site o...
Source: Neuroscience - July 29, 2018 Category: Neuroscience Source Type: research
Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke
Publication date: Available online 29 July 2018Source: NeuroscienceAuthor(s): Murielle G. Kluge, Kimberley Jones, Lin Kooi Ong, Emma K. Gowing, Michael Nilsson, Andrew N. Clarkson, Frederick R. WalkerAbstractDespite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate about translation and generalizability of these results. We were interested in potential age differences in stroke-induced secondary neurodegeneration (SND). SND involves the death of neurons in areas remote from, but connected to, the site...
Source: Neuroscience - August 2, 2018 Category: Neuroscience Source Type: research
Neuroprotection by insulin-like growth factor-1 in rats with ischemic stroke is associated with microglial changes and a reduction in neuroinflammation
Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Ahmad Serhan, Joeri L. Aerts, EWGM Boddeke, Ron KooijmanAbstractWe and others have shown that insulin-like growth factor-1 (IGF-1) is neuroprotective when administered systemically shortly following stroke. In the current study, we addressed the hypothesis that microglia mediate neuroprotection by IGF-1 following ischemic stroke. Furthermore, we investigated whether IGF-1 modulates pro- and anti-inflammatory mediators in ischemic brain with a special reference to microglia. Ischemic stroke was induced in normal conscious Wistar rats by infusi...
Source: Neuroscience - December 16, 2019 Category: Neuroscience Source Type: research
Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model
In this study, in contrast to the global inhibition of p53 function by pharmacological inhibitors and in traditional p53 ko mice, we utilized a neuronal specific conditional ko mouse line (CamcreTRP53 loxP/loxP) to achieve forebrain neuronal specific deletion of p53 and examined the role of the p53 gene in ischemia-induced cell death in neurons. Expression of p53 after stroke is examined using the immunohistochemical method and the outcome of stroke is examined by analysis of infarction size and behavioral deficits caused by stroke. Our data showed that p53 expression is upregulated in the ischemic region in neuronal cells...
Source: Neuroscience - April 6, 2015 Category: Neuroscience Source Type: research
Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats
Publication date: 2 June 2016 Source:Neuroscience, Volume 324 Author(s): J. Hu, B. Liu, Q. Zhao, P. Jin, F. Hua, Z. Zhang, Y. Liu, K. Zan, G. Cui, X. Ye High-mobility group box 1 (HMGB1), a ligand of receptor for advanced glycation endproducts (RAGE), functions as a proinflammatory factor. It is mainly involved in inflammatory activation and contributes to the initiation and progression of stroke. By using a model of transient middle cerebral artery occlusion (MCAo) in type 2 diabetic rats, we investigated the changes of pro-inflammation mediators, blood–brain barrier (BBB) leakage and functional outcome afte...
Source: Neuroscience - March 13, 2016 Category: Neuroscience Source Type: research
Constitutive PGC-1 α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke
Publication date: 1 August 2018 Source:Neuroscience, Volume 384 Author(s): Lars Karlsson, María Nazareth González-Alvarado, Mar Larrosa-Flor, Ahmed Osman, Mats Börjesson, Klas Blomgren, Hans Georg Kuhn Physical exercise can improve morphological outcomes after ischemic stroke and ameliorate irradiation-induced reduction of hippocampal neurogenesis in rodents, but the mechanisms underlying these effects remain largely unknown. The transcription factor peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is considered to be one of the central factors responsible for exercise-induced benefits in ...
Source: Neuroscience - June 14, 2018 Category: Neuroscience Source Type: research
Effect of mirror therapy on recovery of stroke survivors: A systematic review and network meta-analysis
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Yue Yang, Qingchun Zhao, Yingshi Zhang, Qiong Wu, Xiaowen Jiang, Gang ChengAbstractMirror therapy (MT) as a relatively new rehabilitation technique has been widely applied in stroke patients. A number of randomized controlled trials (RCTs) have investigated the effects of MT for stroke survivors. The main purpose of this network meta-analysis was to investigate the effects of MT on motor function, activities of daily living (ADL), and pain perception in stroke survivors. Several databases were searched to identify RCTs evaluating the effects of MT...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
SNHG12 promotes angiogenesis following ischemic stroke via regulating miR-150/VEGF pathway
In conclusion, SNHG12 promotes the angiogenesis following ischemic stroke via miR-150/VEGF pathway, which further clarified the mechanism of angiogenesis after ischemic stroke and provides a target for the treatment of this disease.
Source: Neuroscience - September 5, 2018 Category: Neuroscience Source Type: research
Stroke longitudinal volumetric measures correlate with the behavioral score in non-human primates
Publication date: Available online 24 November 2018Source: NeuroscienceAuthor(s): Gabriel Ramirez-Garcia, Kathleen A. Harrison, Juan Fernandez-Ruiz, Joseph Y. Nashed, Douglas J. CookAbstractStroke is the second leading cause of death worldwide. Brain imaging data from experimental rodent stroke models suggest that size and location of the ischemic lesion relate to behavioral outcome. However, such a relationship between these two variables has not been established in Non-Human Primate (NHP) models. Thus, we aimed to evaluate whether size, location, and severity of stroke following controlled Middle Cerebral Artery Occlusio...
Source: Neuroscience - November 25, 2018 Category: Neuroscience Source Type: research
Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats
We examined whether forced limb-use which mimicked CIMT could influence ischemia-induced neurogenesis, apoptosis and behavioral recovery in the aged rats. Aged rats were divided into a sham group, an ischemia group, and an ischemia group with forced limb-use. Focal cerebral ischemia was induced by injection of endothelin-1. Forced limb-use began on post-stroke day 7 by fitting a plaster cast around the unimpaired upper limbs of rats for 3weeks. Behavioral recovery was evaluated by tapered/ledged beam-walking test on postoperative day 32. The expression of doublecortin, neuronal nuclei, glial fibrillary acidic protein and I...
Source: Neuroscience - December 25, 2014 Category: Neuroscience Source Type: research
