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Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model
CONCLUSION: The site of C7 neurotomy affects MPWT and spinal cord glial proliferation in rats with MCAO. Nerve division closer to intervertebral foramen resulted in lower MPWT and higher degree of glial proliferation in the spinal cord.PMID:35371367 | PMC:PMC8967577 | DOI:10.1155/2022/7446482
Source: Pain Research and Management - April 4, 2022 Category: Anesthesiology Authors: Zhenpeng Li Jintao Fang Jiantao Yang Bengang Qin Wenting He Jian Qi Qingtang Zhu Honggang Wang Liqiang Gu Source Type: research

Effect of Electroacupuncture on Shoulder Subluxation in Poststroke Patients with Hemiplegic Shoulder Pain: A Sham-Controlled Study Using Multidimensional Musculoskeletal Ultrasound Assessment
CONCLUSIONS: Using VAS for measuring pain intensity and multidimensional musculoskeletal ultrasound imaging technique for measuring shoulder subluxation, this study finds that the hemiplegic shoulder pain can be improved significantly by the EA while the shoulder subluxation cannot be. Our findings further reveal the analgesic mechanism of EA on hemiplegic shoulder pain following stroke.PMID:34840636 | PMC:PMC8626186 | DOI:10.1155/2021/5329881
Source: Pain Research and Management - November 29, 2021 Category: Anesthesiology Authors: Minghong Sui Naifu Jiang Luhui Yan Jiaqing Liu Bin Luo Chenxi Zhang Tiebin Yan Yun Xiang Guanglin Li Source Type: research

Human Urinary Kallidinogenase Reduces Lipopolysaccharide-Induced Neuroinflammation and Oxidative Stress in BV-2 Cells.
Abstract Migraine is one of the most common neurological disorders which poses significant socioeconomic burden worldwide. Neuroinflammation and oxidative stress both play important roles in the pathogenesis of migraine. Human urinary kallidinogenase (UK) is a tissue kallikrein derived from human urine. Increasing evidence suggests that UK may protect against ischemic stroke, but UK's treatment potential against migraine remains to be explored. Immortal BV-2 murine microglial cells were treated with UK (125 nM, 250 nM, and 500 nM) and then given lipopolysaccharides (LPS, 1000 ng/mL). Cell viability of BV-2...
Source: Pain Research and Management - August 21, 2019 Category: Anesthesiology Authors: Zhao Z, Xu Z, Liu T, Huang S, Huang H, Huang X Tags: Pain Res Manag Source Type: research

Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study.
Conclusion: The risk of cognitive decline increased in chronic migraine patients. Nonsteroid anti-inflammatory drugs overuse had no influence on cognitive performances among chronic migraine sufferers. PMID: 31198478 [PubMed - in process]
Source: Pain Research and Management - June 15, 2019 Category: Anesthesiology Authors: Cai X, Xu X, Zhang A, Lin J, Wang X, He W, Fang Y Tags: Pain Res Manag Source Type: research

Assessment of pain response in capsaicin-induced dynamic mechanical allodynia using a novel and fully automated brushing device.
CONCLUSIONS: A controlled, automatic brushing method can be used for quantitative investigations of allodynic reactions, and is more reliable for quantitative assessment of dynamic mechanical allodynia compared with traditional manual brushing. PMID: 23457680 [PubMed - indexed for MEDLINE]
Source: Pain Research and Management - January 1, 2013 Category: Anesthesiology Authors: du Jardin KG, Gregersen LS, Røsland T, Uggerhøj KH, Petersen LJ, Arendt-Nielsen L, Gazerani P Tags: Pain Res Manag Source Type: research