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A Novel NOTCH3 Gene Mutation in a Polish CADASIL Family
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a genetically determined disease of the cerebral vessels, characterized by recurrent ischemic strokes, dementia, and degeneration of the cerebral white matter. The condition is caused by a mutation in the NOTCH3 gene, whose product plays a great role in the development and physiology of the cardiovascular system. Magnetic resonance imaging reveals multiple hyperintensive lesions of the white matter in the T2-weighted images also in asymptomatic carriers of CADASIL and can be detected even 10-15 years prior to clinical signs.
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2018 Category: Neurology Authors: Karolina Machowska- Sempruch, Anna Bajer- Czajkowska, Karol Makarewicz, Karolina Zarycza ńska, Adam Koryzma, Przemysław Nowacki Source Type: research

Upstream Stimulating Factor 1 (USF-1) Gene Polymorphisms and the Risk, Symptoms, and Outcome of Pediatric Ischemic Stroke
Pediatric ischemic stroke is an important cause of morbidity and mortality. As previous studies of children after stroke showed, dyslipidemias were very common in Polish and other European populations. Thus, looking for genetic factors predisposing to pediatric stroke, its symptoms, and outcome, we have analyzed 2 polymorphisms of the upstream stimulating factor 1 (USF-1) gene.
Source: Journal of Stroke and Cerebrovascular Diseases - March 26, 2018 Category: Neurology Authors: Anna Balcerzyk, Pawe ł Niemiec, Tomasz Iwanicki, Tomasz Nowak, Ilona Kopyta, Ewa Emich-Widera, Ewa Pilarska, Karolina Pienczk-Ręcławowicz, Marek Kaciński, Janusz Wendorff, Sylwia Górczyńska-Kosiorz, Władyslaw Grzeszczak, Iwona Żak Source Type: research

Infections Diagnosed after Admission to a Stroke Unit and Their Impact on Hospital Mortality in Poland from 1995 to 2015
Implementation of modern stroke unit care might have attenuated the negative effect of infections on stroke outcome. Our aim was to investigate changes in the occurrence of pneumonia and urinary infections diagnosed after admission to experienced Polish stroke center between 1995 and 2015, and their association with hospital mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - March 8, 2018 Category: Neurology Authors: Michal A. Karlinski, Jan P. Bembenek, Anna Baranowska, Iwona Kurkowska-Jastrzebska, Anna Czlonkowska Source Type: research

Metabolic Syndrome in Polish Ischemic Stroke Patients
Metabolic syndrome (MetS) predisposes individuals to cardiovascular disease or stroke development. We aimed at evaluating the prevalence of MetS in a population of acute ischemic stroke (IS) patients from central Poland and at estimating the relationship between MetS and stroke risk.
Source: Journal of Stroke and Cerebrovascular Diseases - July 7, 2015 Category: Neurology Authors: Waldemar Brola, Piotr Sobolewski, Małgorzata Fudala, Anna Goral, Marta Kasprzyk, Wiktor Szczuchniak, Renata Pejas-Dulewicz, Wojciech Przybylski Source Type: research