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Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches
Brain Struct Funct. 2022 May 3. doi: 10.1007/s00429-022-02494-x. Online ahead of print.ABSTRACTGliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i.e., tractography based) and indirect (i.e., atlas-based) approaches to quantifying WM structural disconnections in a cohort of 44 high- and low-grade glioma patients. While these metho...
Source: Brain Structure and Function - May 3, 2022 Category: Neuroscience Authors: Erica Silvestri Umberto Villani Manuela Moretto Maria Colpo Alessandro Salvalaggio Mariagiulia Anglani Marco Castellaro Silvia Facchini Elena Monai Domenico D'Avella Alessandro Della Puppa Diego Cecchin Maurizio Corbetta Alessandra Bertoldo Source Type: research

The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease.
Abstract Microglia undergo a process of activation in pathology which is controlled by many factors including neurotransmitters. We found that a subpopulation (11 %) of freshly isolated adult microglia respond to the muscarinic acetylcholine receptor agonist carbachol with a Ca(2+) increase and a subpopulation of similar size (16 %) was observed by FACS analysis using an antibody against the M3 receptor subtype. The carbachol-sensitive population increased in microglia/brain macrophages isolated from tissue of mouse models for stroke (60 %) and Alzheimer's disease (25 %), but not for glioma and multiple sclero...
Source: Brain Structure and Function - December 19, 2014 Category: Neuroscience Authors: Pannell M, Meier MA, Szulzewsky F, Matyash V, Endres M, Kronenberg G, Prinz V, Waiczies S, Wolf SA, Kettenmann H Tags: Brain Struct Funct Source Type: research