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Chloroquine pretreatment attenuates ischemia-reperfusion injury in the brain of ob/ob diabetic mice as well as wildtype mice.
In conclusion, chloroquine pretreatment could reduce cerebral damage after ischemic stroke especially in diabetic mice through multiple mechanisms, which include reducing neural cell DNA injury, restoring euglycemia and anti-inflammatory effects. The findings may provide potential for the development of chloroquine in the prevention and treatment of stroke in diabetic high-risk patients. PMID: 31647899 [PubMed - as supplied by publisher]
Source: Brain Research - October 20, 2019 Category: Neurology Authors: Zhang YP, Cui QY, Zhang TM, Yi Y, Nie JJ, Xie GH, Wu JH Tags: Brain Res Source Type: research