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Source: Neuroscience Letters
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Total 146 results found since Jan 2013.
Phasic GABA signaling mediates the protective effects of cTBS against cerebral ischemia in mice
Publication date: Available online 4 November 2019Source: Neuroscience LettersAuthor(s): Yi-wei Feng, Yi-qing Huang, Ying Yan, Ge Li, Xiao-fei He, Feng-yin Liang, Zhong Pei, Yue Lan, Guang-qing XuAbstractContinuous theta burst stimulation (cTBS) has been widely recognized as a therapeutic treatment for ischemic stroke, but the underlying mechanism is still elusive. Here, we investigated the protective effects of cTBS in the posterior parietal cortex during the chronic phase of stroke in the photothrombotic ischemic model. Infarction volume and neuron excitability in the peri-infarct area were assessed using immunohistochem...
Source: Neuroscience Letters - November 5, 2019 Category: Neuroscience Source Type: research
A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model
In this study, we subjected adult male Sprague-Dawley rats to 90-min middle cerebral artery (MCA) occlusion followed by reperfusion. Edaravone was treated twice via tail vein; after MCA occlusion and after reperfusion. As expected, edaravone-treated group showed less infarct volume and edema formation compared with control group at 24-h after an ischemic onset. Furthermore, edaravone reduced the levels of plasma interleukin (IL)-1β and matrix metalloproteinase-9 at 3-h after ischemic onset. Several molecules besides IL-1β and MMP-9 are involved in inflammatory responses under stroke conditions. Therefore, we also examine...
Source: Neuroscience Letters - September 14, 2016 Category: Neuroscience Source Type: research
Continuous and not continuous 2-week treadmill training enhances the performance in the passive avoidance test in ischemic gerbils
This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15min, with the speed set at 10m/min, and the training started 24h after the stroke. In the Shuttle Box, each animal had ten trials during the Learning Session (LS), which occur...
Source: Neuroscience Letters - December 16, 2017 Category: Neuroscience Source Type: research
Increased frequency of circulating regulatory T cells in patients with acute cerebral hemorrhage
In this study, a total of 90 ICH patients and 60 healthy controls were recruited. The frequency of circulating Tregs, plasma levels of TGF-β and IL-10, and the severity of neural dysfunction in ICH patients were investigated at different time points post ICH. We found that the peripheral frequency of Tregs in ICH patients was significantly increased, accompanied by boosted activated T cells. Importantly, the elevation of circulating Tregs in patients with severe dysfunction was much higher than that in less-severe patients, suggesting that disease severity affects circulating Tregs to exert regulatory function. Furthermor...
Source: Neuroscience Letters - March 3, 2015 Category: Neuroscience Source Type: research
The CB1 antagonist, SR141716A, is protective in permanent photothrombotic cerebral ischemia
Publication date: 6 September 2016 Source:Neuroscience Letters, Volume 630 Author(s): Zachary Wilmer Reichenbach, Hongbo Li, Sara Jane Ward, Ronald F. Tuma Modulation of the endocannabinoid system has been shown to have a significant impact on outcomes in animal models of stroke. We have previously reported a protective effect of the CB1 antagonist, SR141716A, in a transient reperfusion mouse model of cerebral ischemia. This protective effect was in part mediated by activation of the 5HT1A receptor. Here we have examined its effect in a mouse model of permanent ischemia induced by photoinjury. The CB1 antagonist was ...
Source: Neuroscience Letters - July 25, 2016 Category: Neuroscience Source Type: research
Neuroprotective effect of mesenchymal stem cell through complement component 3 downregulation after transient focal cerebral ischemia in mice
Publication date: Available online 20 September 2016 Source:Neuroscience Letters Author(s): Hye-Seon Jung, Si-Yeon Jeong, Jiwon Yang, So-Dam Kim, Baojin Zhang, Hyun Seung Yoo, Sun U. Song, Myung-Shin Jeon, Yun Seon Song Bone marrow-derived mesenchymal stem cells (MSCs) are used in stroke treatment despite the poor understanding of its mode of action. The immune suppressive and anti-inflammatory properties of MSCs possibly play important roles in regulating neuroinflammation after stroke. We investigated whether MSCs reduce the inflammatory complement component 3 (C3) levels, thus, providing neuroprotection during stroke. ...
Source: Neuroscience Letters - September 20, 2016 Category: Neuroscience Source Type: research
Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats
Publication date: 20 November 2018Source: Neuroscience Letters, Volume 687Author(s): Ning Li, Xiubao Song, Liangmiao Wu, Tao Zhang, Chen Zhao, Xifei Yang, Luchen Shan, Pei Yu, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun ZhangAbstractMiconazole, a frequently used antifungal drug, has been identified with new functions to promote oligodendrocyte progenitor cells differentiation and to enhance remyelination. However, the neuroregenerative and therapeutic benefit of miconazole on ischemic stroke model have not been tested. In the present study, the effects of miconazole on a rat model of transient middle cerebral artery occ...
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research
The loss of estrogen efficacy against cerebral ischemia in aged postmenopausal female mice
Publication date: 13 January 2014 Source:Neuroscience Letters, Volume 558 Author(s): Min Cai , Yu-Long Ma , Pei Qin , Yan Li , Li-Xia Zhang , Huang Nie , Zhengwu Peng , Hui Dong , Hai-Long Dong , Wu-Gang Hou , Li-Ze Xiong Estrogen has been shown to have neuroprotective effects in numerous experimental studies involving young and adult animals. However, several clinical trials have found that in aged postmenopausal women who received estrogen replacement therapy, there did not appear to be a reduction in the incidence of stroke. The aim of this study was to investigate the effects of physiological dosages of estrogen on a...
Source: Neuroscience Letters - November 4, 2014 Category: Neuroscience Source Type: research
A study of ER stress in rat model of cerebral venous sinus thrombosis
Publication date: 4 March 2015 Source:Neuroscience Letters, Volume 589 Author(s): Hari Shanker Tiwari , Amit Kumar Tripathi , Durga Prasad Mishra , Jayantee Kalita , Usha Kant Misra Cerebral venous sinus thrombosis (CVST) is a rare form of stroke. The role of endoplasmic reticulum (ER) stress markers is well documented in arterial stroke but has not been evaluated in venous stroke. The present study has been undertaken to investigate the role of ER stress in rodent model of CVST. For inducing CVST, a cranial window was made to expose superior sagittal sinus (SSS). A strip of filter paper soaked with 40% ferric chloride w...
Source: Neuroscience Letters - January 25, 2015 Category: Neuroscience Source Type: research
miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1
In this study, we found miR-487b was up-regulated in the plasma of ischemic stroke patients. Further, over-expression of miR-487b enhanced cell proliferation, migration, invasion and tube formation in human umbilical vein endothelial cells. Using bioinformatic analysis, we found a putative binding site of miR-487b in the 3′ untranslated regions of Thrombospondin 1 mRNA, an endogenous inhibitor of angiogenesis. This direct binding was confirmed by luciferase assay. These results demonstrate that miR-487b regulates angiogenesis by directly targeting THBS1 in HUVECs, indicating that miR-487b may contribute to angiogenesis a...
Source: Neuroscience Letters - March 3, 2015 Category: Neuroscience Source Type: research
A new middle cerebral artery occlusion model for intra-arterial drug infusion in rats
Publication date: 21 October 2015 Source:Neuroscience Letters, Volume 607 Author(s): Wen-hao Sun, Hui-sheng Chen With the wide application of intra-arterial therapy for cerebrovascular disorders, preclinical intra-arterial drug-delivery studies based on middle cerebral artery occlusion (MCAO) models have become urgent. In the present study, a novel stroke model was developed for intra-arterial drug delivery: MCAO and drug delivery were accomplished using a microcatheter device. MCAO was induced in Sprague-Dawley rats using the microcatheter device (cMCAO group, n =10) or a nylon suture (sMCAO group, n =10). After 24-h ...
Source: Neuroscience Letters - October 4, 2015 Category: Neuroscience Source Type: research
Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes
This study was to investigate the efficacy of puerarin on autophagy in the ischemic penumbra after cerebral stroke. A model of cerebral stroke in Sprague-Dawley rats was prepared by middle cerebral artery occlusion (MCAO); rats were then randomly divided into 5 groups: MCAO+Pue group (rats were treated with puerarin), MCAO+Pue+Tat-Beclin-1 group (rats were administrated with both puerarin and autophagy inducer Tat-Beclin-1), MCAO+Tat-Beclin-1 group (rats were treated with Tat-Beclin-1), MCAO+saline group (rats were administrated with the same volume of physiological saline), and sham surgery group. The autophagy levels in ...
Source: Neuroscience Letters - February 16, 2017 Category: Neuroscience Source Type: research
Analysis of long non-coding RNA expression profiles following focal cerebral ischemia in mice
Publication date: 5 February 2018 Source:Neuroscience Letters, Volume 665 Author(s): Cuiying Liu, Jian Yang, Chencheng Zhang, Menglei Liu, Xiaokun Geng, Xunming Ji, Huishan Du, Heng Zhao Long noncoding RNAs (lncRNAs) have a variety of biological functions and play key roles in many diseases. However, the knowledge of lncRNA function during a stroke is limited. We analyzed the expression profiles of lncRNAs in the brain ischemic region of mice after a 45min middle cerebral artery occlusion (MCAO) with a 48h reperfusion. Gene ontology and pathway analysis were used to elucidate the potential functions of the differentially ...
Source: Neuroscience Letters - December 16, 2017 Category: Neuroscience Source Type: research
Involvement of angiotensin-(1-7) in the neuroprotection of captopril against focal cerebral ischemia
In this study, we evaluate this hypothesis using a rat model of focal cerebral ischemia. We revealed that brain ACE2 activity and Ang-(1-7) levels were significantly elevated following captopril treatment in rats with focal cerebral ischemia. More importantly, we showed that the neuroprotection provided by captopril was partially reversed by A-779, an antagonist for Ang-(1-7) receptor MAS1, indicating that Ang-(1-7) was involved in the neuroprotection of captopril. These findings have uncovered new mechanisms by which captopril protects against focal cerebral ischemia and further suggest that captopril may have practical c...
Source: Neuroscience Letters - September 14, 2018 Category: Neuroscience Source Type: research
Involvement of angiotensin-(1–7) in the neuroprotection of captopril against focal cerebral ischemia
In this study, we evaluated this hypothesis using a rat model of focal cerebral ischemia. We revealed that brain ACE2 activity and Ang-(1–7) levels were significantly elevated following captopril treatment in rats with focal cerebral ischemia. More importantly, we showed that the neuroprotection provided by captopril was partially reversed by A-779, an antagonist for Ang-(1–7) receptor MAS1, indicating that Ang-(1–7) was involved in the neuroprotection of captopril. These findings have uncovered new mechanisms by which captopril protects against focal cerebral ischemia and further suggest that captopril may have prac...
Source: Neuroscience Letters - September 21, 2018 Category: Neuroscience Source Type: research
