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Source: Neuroscience Letters
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Total 146 results found since Jan 2013.
A structural motor network correlates with motor function and not impairment post stroke
This study demonstrates that a broader motor network, like the SMN, is functionally meaningful. Given that the motor network is widely distributed, the proposed SMN warrants further investigation as a potential adjunct biomarker to characterize recovery potential after stroke.
Source: Neuroscience Letters - September 2, 2017 Category: Neuroscience Source Type: research
Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
Publication date: 14 February 2018 Source:Neuroscience Letters, Volume 666 Author(s): Nina Kosi, Ivan Alić, Iva Salamon, Dinko Mitrečić Although transplantation of stem cells improves recovery of the nervous tissue, little is known about the influence of different brain regions on transplanted cells. After we confirmed that cells with uniform differentiation potential can be generated in independent experiments, one million of neural stem cells isolated from B6.Cg-Tg(Thy1-YFP)16Jrs/J mouse embryos were transplanted into the brain 24 h after induction of stroke. The lateral ventricles, the corpus callosum and the stri...
Source: Neuroscience Letters - January 4, 2018 Category: Neuroscience Source Type: research
Motor Imagery Based Brain-Computer Interface Control of Continuous Passive Motion for Wrist Extension Recovery in Chronic Stroke Patients
Publication date: Available online 27 December 2019Source: Neuroscience LettersAuthor(s): Rong-Rong Lu, Mou-Xiong Zheng, Jie Li, Tian-Hao Gao, Xu-Yun Hua, Gang Liu, Song-Hua Huang, Jian-Guang Xu, Yi WuAbstractMotor recovery of wrist and fingers is still a great challenge for chronic stroke survivors. The present study aimed to verify the efficiency of motor imagery based brain-computer interface (BCI) control of continuous passive motion (CPM) in the recovery of wrist extension due to stroke. An observational study was conducted in 26 chronic stroke patients, aged 49.0 ± 15.4 years, with upper extremity motor impairme...
Source: Neuroscience Letters - December 28, 2019 Category: Neuroscience Source Type: research
BDNF genotype influence the efficacy of rTMS in stroke patients
In this study we established personalized stimulus intensity of facilitatory rTMS according to BDNF genotype in stroke patients. Twenty-two chronic stroke patients were enrolled. All patients underwent three different sessions of rTMS over the ipsilesional M1 in randomized order with a washout period exceeding 24h: first condition, high-frequency rTMS with sub-threshold intensity; second condition, high-frequency rTMS with supra-threshold intensity; third condition, sham rTMS. Cortical excitability in the affected hemisphere was assessed with motor evoked potentials (MEPs) before and after stimulation. Data were analyzed a...
Source: Neuroscience Letters - April 3, 2015 Category: Neuroscience Source Type: research
Intraventricular Infusion of a Low Fraction of Serum Enhances Neurogenesis and Improves Recovery in a Rodent Stroke Model
In this study, we further evaluated the efficacy of intraventricular administration of 100K with bFGF (100K/bFGF) in a rat model of transient middle cerebral artery occlusion (MCAO). Rats administered 100K/bFGF on post-stroke day 1 exhibited a higher number of Ki67 and Nestin immunoreactive cells at the subventricular zone (SVZ) area and in the infarcted brain, indicating promotion of NSPCs proliferation. The 100K/bFGF treatment also predominantly increased the number of MAP-2 immunoreactive cells rather than GFAP immunoreactive cells at the SVZ area and in the infarcted regions, implying that 100K/bFGF dominated NSPCs dif...
Source: Neuroscience Letters - November 20, 2015 Category: Neuroscience Source Type: research
Serum miR-132 is a risk marker of post-stroke cognitive impairment
Conclusions These results indicated that there was a substantial correlation between serum miR-132 expression and post-stroke cognitive functionality, suggesting that miR-132 may be a risk marker for PSCI. Because of the limitations of this study, the results should be treated with caution.
Source: Neuroscience Letters - January 30, 2016 Category: Neuroscience Source Type: research
Structural and functional improvements due to robot-assisted gait training in the stroke-injured brain
Publication date: Available online 21 November 2016 Source:Neuroscience Letters Author(s): Hea Eun Yang, Sunghyon Kyeong, Seung Hwa Lee, Won-Jae Lee, Sang Won Ha, Seung Min Kim, Hyunkoo Kang, Won Min Lee, Chang Soon Kang, Dae Hyun Kim Robot-assisted gait training (RAGT) can improve walking ability after stroke. Because the underlying mechanisms are still unknown, we analyzed changes in post-stroke injured brains after RAGT. Ten non-ambulatory patients receiving inpatient rehabilitation were examined within 3 months of stroke onset. RAGT consisted of 45minutes of training, 3days per week. We acquired diffusion tensor imagi...
Source: Neuroscience Letters - November 21, 2016 Category: Neuroscience Source Type: research
Early hyperbaric oxygen therapy may improve the long term neurological consequences of diabetic patients suffering from hemorrhagic stroke
Conclusions In this study, early HBOT was found to be safe and effective with regards to the long term neurological consequences of diabetic patients suffering from ICH.
Source: Neuroscience Letters - February 27, 2017 Category: Neuroscience Source Type: research
Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke
Conclusions Ectopic expression of HuR in astrocytes worsens outcome after transient ischemic stroke in mice in part by increasing vasogenic cerebral edema. These findings suggest that HuR could be a therapeutic target in cerebral ischemia/reperfusion.
Source: Neuroscience Letters - October 7, 2017 Category: Neuroscience Source Type: research
A new central post-stroke pain rat model: autologous blood injected thalamic hemorrhage involved increased expression of P2X4 receptor
Publication date: 20 November 2018Source: Neuroscience Letters, Volume 687Author(s): Hai-Feng Lu, Chun-Yang Xu, Lei Zhang, Lei Gan, Chan Chen, Man-Yun Yan, Xiao-Ning Guo, Qi Fang, Guang-Yin Xu, Yan-Bo Zhang, Jian-Qiang Ni, Hong-Ru ZhaoAbstractStroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and charac...
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research
Neuronal activity-dependent myelin repair after stroke
Publication date: Available online 20 March 2019Source: Neuroscience LettersAuthor(s): Wanyi Jia, Yasmine Kamen, Helena Pivonkova, Ragnhildur T. KáradóttirAbstractBrain tissue undergoes substantial activity-dependent reorganisation after stroke due to neuronal plasticity, leading to partial functional recovery in patients. Concurrent myelin repair is crucial for proper neuronal network function and reorganisation. Myelin repair after stroke might occur as myelin plasticity or as remyelination through the recruitment and differentiation of oligodendrocyte precursor cells (OPCs), which become myelin-forming oligodendrocyte...
Source: Neuroscience Letters - March 21, 2019 Category: Neuroscience Source Type: research
Simultaneous alterations of oligodendrocyte-specific CNP, astrocyte-specific AQP4 and neuronal NF-L demarcate ischemic tissue after experimental stroke in mice
In conclusion, the present study provides evidence for a simultaneous affection of oligodendrocytes, astrocytes and neurons after experimental focal cerebral ischemia. Consequently, CNP, AQP4 and NF-L immunofluorescence alterations can be utilized to identify ischemia-affected tissue. The simultaneity of the described alterations further strengthens the concept of interdependent NVU components and distinguishes NF-L, CNP and AQP4 as highly ischemia-sensitive elements. Consequently, future therapeutic approaches might influence stroke evolution via strategies simultaneously addressing both neuronal and glial functions.
Source: Neuroscience Letters - July 31, 2019 Category: Neuroscience Source Type: research
Characterization of stimulus response curves obtained with transcranial magnetic stimulation from bilateral tibialis anterior muscles post stroke
ConclusionOur results highlight the differences between non-linear and linear approaches to best fit the SR curves from bilateral TA muscles in stroke survivors. Although the linear function can appropriately fit the SR curve of the paretic and non-paretic TA, the non-linear function estimated a higher slope. We found the AUC to be a more robust measure that was not affected by the type of curve-fitting approach and only the AUC of the paretic TA showed significant association with walking speeds. A better understanding of SR curve fitting approaches for the TA muscles in individuals with chronic stroke allows for their op...
Source: Neuroscience Letters - October 2, 2019 Category: Neuroscience Source Type: research
Contralesional motor cortex is causally engaged during more dexterous actions of the paretic hand after stroke- A Preliminary report
Publication date: Available online 10 January 2020Source: Neuroscience LettersAuthor(s): Shailesh Kantak, Dustin LuchmeeAbstractBilateral activation in motor cortex is observed during paretic hand performance after stroke; however the functional significance of contralesional motor cortex (C-M1) activation is highly debated. Particularly, it is not known if task characteristics such as dexterity influence the causal engagement of C-M1 during paretic hand performance. Transcranial magnetic stimulation (TMS) was used to quantify motor corticospinal physiology of the CM1 projecting to the contralateral resting extensor carpi ...
Source: Neuroscience Letters - January 11, 2020 Category: Neuroscience Source Type: research
ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke
Publication date: 8 October 2015 Source:Neuroscience Letters, Volume 606 Author(s): Barry J. Connell, John R. Gordon, Tarek M. Saleh Inflammation-related cerebral damage mediated by infiltrating neutrophils following reperfusion plays a role in reperfusion-induced brain damage subsequent to a stroke event. The ELR-CXC family of chemokines are CXCR1 and CXCR2 agonists that are known to drive neutrophil migration and activation. The present study demonstrated the benefit of anti-inflammatory therapy in the treatment of ischemic stroke with the administration of the competitive ELR-CXC chemokine antagonist, CXCL8(3–72)...
Source: Neuroscience Letters - September 4, 2015 Category: Neuroscience Source Type: research
