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Source: Clinical Therapeutics

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Total 102 results found since Jan 2013.

Sex Differences in Physical Activity and Incident Stroke: A Systematic Review
Clin Ther. 2022 Apr 10:S0149-2918(22)00076-5. doi: 10.1016/j.clinthera.2022.02.006. Online ahead of print.ABSTRACTPURPOSE: Physical inactivity, a modifiable risk factor for cardiovascular disease, is independently associated with stroke. Though some prior data have suggested sex differences in levels of physical activity, whether there are sex differences in the role of physical activity in primary stroke prevention is largely unknown. This systematic review identifies and describes recent findings on sex differences in the association between physical activity and incident (first-ever) stroke. This review also describes t...
Source: Clinical Therapeutics - April 14, 2022 Category: Drugs & Pharmacology Authors: Tracy E Madsen Mehrnoosh Samaei Aleksandra Pikula Amy Y X Yu Cheryl Carcel Erika Millsaps Ria Sara Yalamanchili Nicole Bencie Adrienne N Dula Michelle Leppert Tatjana Rundek Rachel P Dreyer Cheryl Bushnell Source Type: research

Warfarin Use and Stroke Risk Among Patients With Nonvalvular Atrial Fibrillation in a Large Managed Care Population.
CONCLUSIONS: More than half of patients on warfarin had treatment gaps or discontinued therapy. Therapy gaps were associated with increased stroke risk. PMID: 23867114 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - July 15, 2013 Category: Drugs & Pharmacology Authors: Deitelzweig SB, Buysman E, Pinsky B, Lacey M, Jing Y, Wiederkehr D, Graham J Tags: Clin Ther Source Type: research

Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke.
Abstract PURPOSE: We aimed to investigate the association between stroke morbidity and different stratifications of classic risk factors, such as increasing age, body mass index (BMI), blood lipids, and blood glucose, in hypertensive patients with high homocysteine levels. METHODS: A cross-sectional study of 2258 patients with primary hypertension were enrolled in this study, including 871 stroke cases (62.89%) in 1385 hypertensive patients without hyperhomocysteinemia (HHcy) and 647 (74.11%) stroke cases in 873 hypertensive patients with HHcy. Basic information of patients were collected, including age, sex,...
Source: Clinical Therapeutics - March 23, 2016 Category: Drugs & Pharmacology Authors: Pang H, Han B, Fu Q, Zong Z Tags: Clin Ther Source Type: research

The Impact of Heart Failure and Left Ventricular Dysfunction in Predicting Stroke, Thromboembolism, and Mortality in Atrial Fibrillation Patients: A Systematic Review.
Abstract PURPOSE: Atrial fibrillation (AF) is commonly associated with structural heart disease. Although heart failure (HF) has been proposed as a risk factor for stroke, the coexistence of the 2 diseases increases disproportionally the risk of thromboembolic events. Our objective was to conduct a systematic review to assess the effect of HF on the end points of stroke, systemic embolism (SE), or mortality in patients with AF. METHODS: A literature search was performed to identify studies that examined stroke/ SE in relation to AF and HF. Overall, 405 articles satisfied the preinclusion criteria. FINDIN...
Source: Clinical Therapeutics - August 18, 2014 Category: Drugs & Pharmacology Authors: Agarwal M, Apostolakis S, Lane DA, Lip GY Tags: Clin Ther Source Type: research

Colchicine for Stroke Prevention: A Systematic Review and Meta-Analysis.
Abstract PURPOSE: There has been recent interest in the role of colchicine in cardiovascular diseases, given the implication of inflammation in the pathogenesis of atherothrombosis. This systematic review assessed the role of colchicine in preventing primary or secondary stroke/transient ischemic attack (TIA) in an adult population. METHODS: Four databases were electronically searched: MEDLINE, EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), and OpenGrey. Studies were eligible if they reported stroke or TIA incidence as a primary/secondary end point, or as an adverse event. Only case-control...
Source: Clinical Therapeutics - February 27, 2019 Category: Drugs & Pharmacology Authors: Khandkar C, Vaidya K, Patel S Tags: Clin Ther Source Type: research

Potential Therapeutic Effects of Sodium Glucose-linked Cotransporter 2 Inhibitors in Stroke.
CONCLUSIONS: It is unlikely that SGLT inhibitors have a positive or negative effect on stroke risk, but the question that remains unanswered is whether SGLT inhibitors can yield a protective effect after acute ischemic stroke. Future observational studies and registries may be the first step to help answer this question. (Clin Ther. 2020; XX:XXX-XXX) © 2020 Elsevier HS Journals, Inc. PMID: 33008610 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - September 28, 2020 Category: Drugs & Pharmacology Authors: Al Hamed FA, Elewa H Tags: Clin Ther Source Type: research

Pharmacists Act on Care Transitions in Stroke (PACT-Stroke): A Systems Approach
This study was a single-center, retrospective assessment of patients contacted by a pharmacist. All data were analyzed descriptively. Our initial evaluation of the Pharmacists Act on Care Transitions in Stroke (PACT-Stroke) service was to quantify and categorize drug-related problems (DRPs), which included drug selection, drug form, dose selection, treatment duration, dispensing, drug use process, patient-related problems, and other. Patients were included if they were adults who experienced an ischemic stroke. Exclusion criteria for this service included pediatric patients, patients with hemorrhagic strokes, patients with...
Source: Clinical Therapeutics - February 16, 2022 Category: Drugs & Pharmacology Authors: Jenna L Harris Danielle DelVecchio Robert W Seabury Christopher D Miller Elizabeth Phillips Source Type: research

Cost-Effectiveness of Apixaban Versus Other New Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation.
CONCLUSIONS: Although our analysis was limited by the absence of head-to-head trials, based on the indirect comparison data available, our model projects that apixaban may be a cost-effective alternative to dabigatran 150 mg BID, dabigatran 110 mg BID, and rivaroxaban 20 mg once daily for stroke prevention in AF patients from the perspective of the United Kingdom National Health Services. PMID: 24508420 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - February 5, 2014 Category: Drugs & Pharmacology Authors: Lip GY, Kongnakorn T, Phatak H, Kuznik A, Lanitis T, Liu LZ, Iloeje U, Hernandez L, Dorian P Tags: Clin Ther Source Type: research

Cinnamon and Aspirin for Mild Ischemic Stroke or Transient Ischemic Attack: A Pilot Trial
Clin Ther. 2022 Mar 25:S0149-2918(22)00082-0. doi: 10.1016/j.clinthera.2022.02.012. Online ahead of print.ABSTRACTPURPOSE: Cinnamon can reduce levels of blood lipids, blood glucose, and inflammation, which are risk factors for ischemic stroke and transient ischemic attack (TIA).The goal of this study was to observe the safety and efficacy of aspirin combined with cinnamon in the treatment of patients with mild stroke or TIA.METHODS: This pilot study included patients with mild stroke or TIA treated at Guangdong Provincial People's Hospital-Nanhai Hospital between January 2014 and December 2016. The primary end point was re...
Source: Clinical Therapeutics - March 29, 2022 Category: Drugs & Pharmacology Authors: Lei Zhang Zhanhui Li Yuewen Wu Yanming Fan Zhicong He Peng He Jingxing Liang Source Type: research

Intensive Versus Moderate Statin Therapy Discontinuation in Patients With Acute Ischemic Stroke or Transient Ischemic Attack.
This study aimed to clarify whether intensive statin therapy resulted in a significant increase in discontinuation early after discharge. METHODS: This multicenter registry study enrolled consecutive hospitalized patients with ischemic stroke or transient ischemic attack. All the patients were prescribed statin therapy at discharge. Intensity of statin therapy was defined according to the 2013 American College of Cardiology/American Heart Association guideline on the treatment of blood cholesterol. A logistic regression model was used to analyze the association between statin therapy intensity and discontinuation. ...
Source: Clinical Therapeutics - November 9, 2018 Category: Drugs & Pharmacology Authors: Yuan HW, Ji RJ, Lin YJ, Chen HF, Peng GP, Luo BY Tags: Clin Ther Source Type: research