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Source: Molecular Medicine
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Total 166 results found since Jan 2013.
Prediction of post-stroke cognitive impairment using brain FDG PET: deep learning-based approach
CONCLUSION: The DL-based cognitive signature using FDG PET was successfully transferred to an independent stroke cohort. It is suggested that DL-based cognitive evaluation using FDG PET could be utilized as an objective biomarker for cognitive dysfunction in patients with cerebrovascular diseases.PMID:34599654 | DOI:10.1007/s00259-021-05556-0
Source: Molecular Medicine - October 2, 2021 Category: Molecular Biology Authors: Reeree Lee Hongyoon Choi Kwang-Yeol Park Jeong-Min Kim Ju Won Seok Source Type: research
Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway.
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluate...
Source: Molecular Medicine - March 24, 2019 Category: Molecular Biology Authors: Luo S, Li H, Mo Z, Lei J, Zhu L, Huang Y, Fu R, Li C, Huang Y, Liu K, Chen W, Zhang L Tags: Exp Mol Med Source Type: research
Systemic inflammation after stroke: implications for post-stroke comorbidities
EMBO Mol Med. 2022 Aug 15:e16269. doi: 10.15252/emmm.202216269. Online ahead of print.ABSTRACTImmunological mechanisms have come into the focus of current translational stroke research, and the modulation of neuroinflammatory pathways has been identified as a promising therapeutic approach to protect the ischemic brain. However, stroke not only induces a local neuroinflammatory response but also has a profound impact on systemic immunity. In this review, we will summarize the consequences of ischemic stroke on systemic immunity at all stages of the disease, from onset to long-term outcome, and discuss underlying mechanisms...
Source: Molecular Medicine - August 16, 2022 Category: Molecular Biology Authors: Alba Simats Arthur Liesz Source Type: research
Differential value of intima thickness in ischaemic stroke due to large-artery atherosclerosis and small-vessel occlusion
This study aimed to assess whether intima thickness of carotid artery (CIT), radial artery (RIT) and dorsalis pedis artery (PIT) have an independent and additive value in differentiating ischaemic stroke subtypes due to large-artery atherosclerosis (LAA) or small-vessel occlusion (SVO). One hundred and sixty-one patients with LAA and 79 patients with SVO were recruited. CIT, RIT and PIT were measured with a 24-MHz ultrasound transducer. Binary logistic regression analysis was used to evaluate the differential values of the different parameters in the two subtypes. ROC curve analyses were plotted to compare the differential...
Source: Molecular Medicine - August 30, 2021 Category: Molecular Biology Authors: Suqin Jin Cheng Zhang Yun Zhang Guoyong Jia Mei Zhang Mingjun Xu Source Type: research
Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)
Int J Mol Med. 2022 Feb;49(2):15. doi: 10.3892/ijmm.2021.5070. Epub 2021 Dec 8.ABSTRACTStroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to ischemic strokes, which constitutes the majority of strokes. Ischemic strokes induce brain infarcts, along with cerebral tissue death and focal neuronal damage. The infarct size and neurological severity after ischemic stroke episodes depends on the time period since occurrence, the severity of ischemia, systemic blood pressure, vein systems and location of inf...
Source: Molecular Medicine - December 8, 2021 Category: Molecular Biology Authors: Yunfei Zhao Xiaojing Zhang Xinye Chen Yun Wei Source Type: research
Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials
J Cell Mol Med. 2022 Jan 17. doi: 10.1111/jcmm.17189. Online ahead of print.ABSTRACTMitochondrial damage is a critical contributor to stroke-induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke. Mitochondria quality control promotes neuronal survival via various adaptive responses for preserving mitochondria structure, morphology, quantity and function. The processes of mitochondrial fission and fusion allow for damaged mitochondria to be segregated and facilitate the equilibration of m...
Source: Molecular Medicine - January 18, 2022 Category: Molecular Biology Authors: Heyan Tian Xiangyu Chen Jun Liao Tong Yang Shaowu Cheng Zhigang Mei Jinwen Ge Source Type: research
An In Vivo Mouse Model to Study Blood-Brain Barrier Destabilization in the Chronic Phase of Stroke
Methods Mol Biol. 2022;2492:289-305. doi: 10.1007/978-1-0716-2289-6_17.ABSTRACTCerebral ischemic injury evokes a complex cascade of pathophysiological events at the blood-vascular-parenchymal interface. These evolve over time and space and result in progressive neurological damage. Emerging evidence suggests that blood-brain barrier (BBB) recovery and reestablishment of BBB impermeability are incomplete and that these could influence stroke injury recovery, increase the risk of new stroke occurrence, and be a solid substrate for developing vascular dementia. Recent work from the author's laboratory has established the exis...
Source: Molecular Medicine - June 22, 2022 Category: Molecular Biology Authors: Svetlana M Stamatovic Chelsea M Phillips Richard F Keep Anuska V Andjelkovic Source Type: research
Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke
Curr Mol Med. 2023 Apr 10. doi: 10.2174/1566524023666230410101724. Online ahead of print.ABSTRACTIschemic stroke is one of the major causes of global mortality, which puts great demands on health systems and social welfare. Ischemic stroke is a complex pathological process involving a series of mechanisms such as ROS accumulation, Ca2 + overload, inflammation, and apoptosis. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients has led scientists to find new treatments. The use of herbal medicine, as an alternative or complementary therapy, is increasing worldwide. For centurie...
Source: Molecular Medicine - April 11, 2023 Category: Molecular Biology Authors: Shakiba Azami Fatemeh Forouzanfar Source Type: research
Lipid profiles and atrial fibrillation in ischemic stroke patients treated with thrombectomy: experience from a tertiary Italian stroke hospital
CONCLUSION: Total cholesterol and all cholesterol-related measures were significantly lower in patients undergoing thrombectomy than in other stroke patients. Conversely, we found that AF was significantly high in patients with EVT, suggesting that hypercholesterolemia could be mainly linked to small-vessel occlusion stroke while large vessel occlusion (LVO) stroke could show different causes. AIS patients may have different pathogenesis and their understanding may improve enhance the discovery of specific and tailored preventive treatments.PMID:37221691 | DOI:10.2174/1871525721666230522124351
Source: Molecular Medicine - May 24, 2023 Category: Molecular Biology Authors: Maria Cristina Bravi Fabio Pilato Domenica Crupi Marilena Mangiardi Francesca Romana Pezzella Antonio Siniscalchi Enrico Cotroneo Luca Bertaccini Michele Alessiani Sabrina Anticoli Source Type: research
Bibliometric analysis and visualized study of research on autophagy in ischemic stroke
Conclusion: This bibliometric analysis helps us reveal the current research hotspots in the research field of autophagy in ischemic stroke and guide future research directions. Subsequent trends in this special field are likely to identify and develop novel autophagy-targeted therapy strategies to effectively prevent and treat ischemic stroke.PMID:37731738 | PMC:PMC10507179 | DOI:10.3389/fphar.2023.1232114
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Jiefang Chen Gaijie Chen Xiaojing Xu Long Chen Jiewen Zhang Feng Liu Source Type: research
