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Source: European Journal of Neuroscience

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Total 56 results found since Jan 2013.

Calcium/calmodulin ‐dependent protein kinase kinase β is neuroprotective in stroke in aged mice
This study demonstrates that CaMKK β is neuroprotective following stroke in aged mice. Inhibition of CaMKK β worsened stroke outcome by reducing expression of prosurvival factors, as well as the levels of proteins important for the integrity of blood–brain barrier, and increasing proinflammatory cytokines in the serum after stroke. Conversely, the overexpression of CaMKK β reduced infarcts and behavioral deficits in aged mice.
Source: European Journal of Neuroscience - August 16, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue ‐jun Li, Louise McCullough, Jun Li Tags: Clinical and Translational Neuroscience Source Type: research

Significance of longitudinal changes in the default‐mode network for cognitive recovery after stroke
Abstract Although a considerable number of patients suffer from cognitive impairments after stroke, the neural mechanism of cognitive recovery has not yet been clarified. Repeated resting‐state functional magnetic resonance imaging (fMRI) was used in this study to examine longitudinal changes in the default‐mode network (DMN) during the 6 months after stroke, and to investigate the relationship between DMN changes and cognitive recovery. Out of 24 initially recruited right‐hemispheric stroke patients, 11 (eight males, mean age 55.7 years) successfully completed the repeated fMRI protocol. Patients underwent three f...
Source: European Journal of Neuroscience - June 16, 2014 Category: Neuroscience Authors: Ji‐Young Park, Yun‐Hee Kim, Won Hyuk Chang, Chang‐hyun Park, Yong‐Il Shin, Sung Tae Kim, Alvaro Pascual‐Leone Tags: Research Report Source Type: research

Early stimulation treatment provides complete sensory‐induced protection from ischemic stroke under isoflurane anesthesia
This study demonstrated that the isoflurane‐anesthetised rat pMCAO model can be used for cerebrovascular studies, and allows for highly detailed investigation of potential novel treatments for ischemic stroke using awake, behaving animals. Using a rat model of ischemia (permanent middle cerebral artery occlusion; pMCAO) we demonstrate that whisker stimulation can completely protect the cortex from impending stroke. Furthermore, the broad extent of evoked activity evident under isoflurane anesthesia plays a significant role in the protection from, or deterioration towards infarct. We conclude that the pMCAO model may be ...
Source: European Journal of Neuroscience - April 16, 2013 Category: Neuroscience Authors: Christopher C. Lay, Nathan Jacobs, Aneeka M. Hancock, Yi Zhou, Ron D. Frostig Tags: Research Report Source Type: research

Calcium/Calmodulin‐Dependent Protein Kinase Kinase β (CaMKK β) is Neuroprotective in Stroke in Aged Mice
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - June 15, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue‐jun Li, Louise McCullough, Jun Li Tags: Research Report Source Type: research

Calcium/Calmodulin ‐Dependent Protein Kinase Kinase β (CaMKK β) is Neuroprotective in Stroke in Aged Mice
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - June 15, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue ‐jun Li, Louise McCullough, Jun Li Tags: Research Report Source Type: research

Changes in structure and perfusion of grey matter tissues during recovery from Ischaemic subcortical stroke: a longitudinal MRI study
This study provides the imaging evidence of structural and vascular plasticity after stroke and expands our understanding of neurobiology of stroke recovery.
Source: European Journal of Neuroscience - September 4, 2017 Category: Neuroscience Authors: Xinfeng Yu, Linglin Yang, Ruirui Song, Yerfan Jiaerken, Jun Yang, Min Lou, Quan Jiang, Minming Zhang Tags: Research Report Source Type: research

Effect of stroke on arginase expression and localization in the rat brain
In conclusion, increased arginase 1 expression is not restricted to macrophages in inflammation elicited by stroke but also occurs in activated astrocytes where it may contribute to neuroplasticity through the control of BDNF production. The most striking result of our study is the sustained up‐regulation of arginase 1 in activated astrocytes. These cells, which form the glial scar, are known to express different kinds of inflammatory and anti‐inflammatory mediators and some may alternatively facilitate brain macrophage activation.
Source: European Journal of Neuroscience - January 13, 2013 Category: Neuroscience Authors: Aurore Quirié, Céline Demougeot, Nathalie Bertrand, Claude Mossiat, Philippe Garnier, Christine Marie, Anne Prigent‐Tessier Tags: Research Report Source Type: research

Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice
Abstract Factor VII activating protease (FSAP) is a circulating protease with a putative role in hemostasis, remodeling and inflammation. A polymorphism giving rise to low proteolytic activity has been associated with an increased risk of stroke and carotid stenosis. To date, no in vivo studies or mechanistic information is available to explain these results. Based on the polymorphism data we hypothesize that a lack of endogenous FSAP will increase the severity of stroke. Stroke was induced by applying thrombin in the middle cerebral artery in wild‐type (WT) and FSAP−/− mice. Increased stroke volume and worsened neur...
Source: European Journal of Neuroscience - January 1, 2015 Category: Neuroscience Authors: A. U. Joshi, C. Orset, B. Engelhardt, E. Baumgart‐Vogt, T. Gerriets, D. Vivien, S. M. Kanse Tags: Research Report Source Type: research

Chronic metformin treatment improves post‐stroke angiogenesis and recovery after experimental stroke
Abstract Metformin is currently the first‐line treatment drug for type 2 diabetes. Metformin is a well‐known activator of AMP‐activated protein kinase (AMPK). In experimental studies, metformin has been shown to exert direct vascular effects by increasing vascular endothelial growth factor expression and improving microvascular density. As stroke is the leading cause of long‐term disability and angiogenesis is implicated as an important mechanism in functional recovery, we hypothesized that chronic metformin treatment would improve post‐stroke functional recovery by enhancing functional microvascular density. For...
Source: European Journal of Neuroscience - March 1, 2014 Category: Neuroscience Authors: Venugopal R. Venna, Jun Li, Matthew D. Hammond, Nickolas S. Mancini, Louise D. McCullough Tags: Research Report Source Type: research

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - November 13, 2017 Category: Neuroscience Authors: Abdullah Al Mamun, Anjali Chauhan, Haifu Yu, Yan Xu, Romana Sharmeen, Fudong Liu Tags: Research Report Source Type: research

Changes in Structure and Perfusion of Gray Matter Tissues during Recovery from Ischemic Subcortical Stroke: A Longitudinal MRI Study
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - August 1, 2017 Category: Neuroscience Authors: Xinfeng Yu, Linglin Yang, Ruirui Song, Yerfan Jiaerken, Jun Yang, Min Lou, Quan Jiang, Minming Zhang Tags: Research Report Source Type: research

A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
In this study, elderly male Wistar rats received a combination of two mild transient middle cerebral artery occlusions (tMCAOs) as an in vivo recurrent ischemic model. Primary cultured cortical neuronal cells subjected to combined oxygen–glucose deprivation (OGD) were used as an in vitro recurrent ischemic model. RSV administration significantly reduced infarct volumes, improved behavioral deficits and protected neuronal cells from cell death in recurrent ischemic stroke models in vivo and in vitro. RSV treatments significantly increased the intracellular NAD+/NADH ratio, AMPK and SIRT1 activities, decreased energy assum...
Source: European Journal of Neuroscience - March 5, 2013 Category: Neuroscience Authors: Li‐Mei Wang, Yong‐Jiu Wang, Min Cui, Wen‐Juan Luo, Xiao‐Ji Wang, Philip A. Barber, Zhe‐Yu Chen Tags: Research Report Source Type: research

An EEG Index of Sensorimotor Interhemispheric Coupling after unilateral stroke: clinical and neurophysiological study
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - December 15, 2017 Category: Neuroscience Authors: Floriana Pichiorri, Manuela Petti, Stefano Caschera, Laura Astolfi, Febo Cincotti, Donatella Mattia Tags: Short Communication Source Type: research

Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats
Abstract Using a rodent model of ischemic stroke [permanent middle cerebral artery occlusion (pMCAO)], our laboratory has previously demonstrated that sensory‐evoked cortical activation via mechanical single whisker stimulation treatment delivered under an anesthetized condition within 2 h of ischemic onset confers complete protection from impending infarct. There is a limited time window for this protection; rats that received the identical treatment at 3 h following ischemic onset lost neuronal function and sustained a substantial infarct. Rats in these studies, however, were anesthetized with sodium pentobarbital or...
Source: European Journal of Neuroscience - September 12, 2014 Category: Neuroscience Authors: Christopher C. Lay, Ron D. Frostig Tags: Research Report Source Type: research

Modulation of task ‐related cortical connectivity in the acute and subacute phase after stroke
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - February 21, 2018 Category: Neuroscience Authors: Lisbeth Hoejkjaer Larsen, Ivan Chrilles Zibrandtsen, Troels Wienecke, Troels Wesenberg Kjaer, Henning Langberg, Jens Bo Nielsen, Mark Schram Christensen Tags: Research Report Source Type: research