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Total 262 results found since Jan 2013.

How heavy is the load? The ventricular mechanics of mitral regurgitation revisited in the era of percutaneous therapies
The impact of mitral regurgitation (MR) on left ventricular (LV) function and remodelling has been typically described in terms of a pure volume overload. In fact, LV afterload in MR is sometimes believed to be below normal ‘because the regurgitant orifice allows blood to exit the ventricle with little opposition’. Moreover, this argument sometimes is followed by the idea that a low-afterload leads to overestimate intrinsic LV systolic function in MR. Remarkably, despite a number of authors have emphasised that afterload is not reduced in chronic MR,1 2 the idea is still prevalent. Describing MR merely as a vol...
Source: Heart - March 28, 2017 Category: Cardiology Authors: Martinez-Legazpi, P., Yotti, R., Bermejo, J. Tags: Drugs: cardiovascular system, Hypertension, Mitral valve disease, Right sided valvular heart disease Editorials Source Type: research

Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation
Conclusions In ARISTOTLE, non-major bleeding was common and substantially less frequent with apixaban than with warfarin. CRNM bleeding was independently associated with a higher risk of death and subsequent major bleeding. Our results highlight the importance of any severity of bleeding in patients with AF treated with anticoagulation therapy and suggest that non-major bleeding, including minor bleeding, might not be minor. Trial registration number NCT00412984; post-results.
Source: Heart - March 28, 2017 Category: Cardiology Authors: Bahit, M. C., Lopes, R. D., Wojdyla, D. M., Held, C., Hanna, M., Vinereanu, D., Hylek, E. M., Verheugt, F., Goto, S., Alexander, J. H., Wallentin, L., Granger, C. B. Tags: Open access, Drugs: cardiovascular system Arrhythmias and sudden death Source Type: research

Cautious anticoagulation strategy in patients with dialysis-requiring end-stage kidney disease
To the Editor: We read with interest this manuscript which demonstrated in a large clinical registry that patients with chronic kidney disease with indications for anticoagulation were often treated subtherapeutically.1 A more aggressive approach was, therefore, advocated. We would like to point out that, while this study should be commended for including a large number of patients, it did not show data on the key clinical outcomes of stroke or bleeding. We feel, therefore, that a clear association cannot be made between low time in the therapeutic range (TTR) and any negative clinical outcome. In fact, paradoxically,...
Source: Heart - March 28, 2017 Category: Cardiology Authors: Behar, J. M., Forbes, S. H., Wragg, A., Sporton, S. Tags: Correspondence Source Type: research

Long-term prognostic impact of left atrial volumes and emptying fraction in a community-based cohort
Conclusions In this community-based cohort, LAEF was a powerful predictor of incident cardiovascular events and its predictive ability was stronger than for LA volumes. Our findings suggest that LA dysfunction may represent a more advanced state of LA remodelling than LA enlargement.
Source: Heart - April 10, 2017 Category: Cardiology Authors: Hedberg, P., Selmeryd, J., Leppert, J., Henriksen, E. Tags: Drugs: cardiovascular system, Echocardiography, Acute coronary syndromes, Clinical diagnostic tests Heart failure and cardiomyopathies Source Type: research

Tea consumption and risk of ischaemic heart disease
Conclusions In this large prospective study, daily tea consumption was associated with a reduced risk of IHD.
Source: Heart - April 26, 2017 Category: Cardiology Authors: Li, X., Yu, C., Guo, Y., Bian, Z., Si, J., Yang, L., Chen, Y., Ren, X., Jiang, G., Chen, J., Chen, Z., Lv, J., Li, L., on behalf of the China Kadoorie Biobank Collaborative Group Tags: Open access Cardiac risk factors and prevention Source Type: research

Oral anticoagulation in end-stage renal disease and atrial fibrillation: is it time to just say no to drugs?
Atrial fibrillation (AF) frequently complicates the management of chronic kidney disease, especially in patients with end-stage renal disease (ESRD). AF occurs in approximately one in five of the 650 000 patients with ESRD in the USA.1 ESRD confers increased risk for AF, while AF hastens progression to ESRD. The presence of chronic kidney disease in patients with AF is associated with an increased risk for ischaemic stroke independent of traditional risk factors. In addition, chronic kidney disease and particularly ESRD are associated with an increased risk of bleeding. Little is understood about how to safely reduce ...
Source: Heart - May 10, 2017 Category: Cardiology Authors: Black-Maier, E., Piccini, J. P. Tags: Editorials Source Type: research

Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease
Conclusions The PREDICT-CVD secondary prevention score uses routine measurements from clinical practice that enable it to be implemented in a primary care setting. The score will facilitate risk communication between primary care practitioners and patients with prior CVD, particularly as a resource to show the benefit of risk factor modification.
Source: Heart - May 31, 2017 Category: Cardiology Authors: Poppe, K. K., Doughty, R. N., Wells, S., Gentles, D., Hemingway, H., Jackson, R., Kerr, A. J. Tags: Cardiac risk factors and prevention Source Type: research

Contemporary management of persistent atrial fibrillation
Learning objectives Develop a basic understanding of the underlying mechanisms of atrial fibrillation and classification of the disease. Review the main principles in contemporary management of atrial fibrillation with a focus on persistent atrial fibrillation. Discuss catheter ablation in the context of atrial fibrillation. Introduction Atrial fibrillation (AF) is a multisystemic disorder that is associated with an excess risk of stroke, heart failure and mortality.1 It remains the most common sustained arrhythmia and its significance should not be underestimated. Research focused on unveiling the mechanisms of AF began o...
Source: Heart - December 22, 2021 Category: Cardiology Authors: Gupta, D., Ding, W. Y. Tags: Education in Heart Source Type: research

Response to: Correspondence on "Association between cardiologist evaluation and mortality in myocardial injury after non-cardiac surgery" by Müller et al
The Authors’ reply: In response to valuable comments by Müller et al,1 we are pleased to share results of additional analysis on our recent study ‘Association between cardiologist evaluation and mortality in myocardial injury after non-cardiac surgery’.2 We hope the additional information would be helpful for readers. First, we agree with the concern and conducted analysis on 2322 myocardial injury after non-cardiac surgery patients who had preoperative cardiac troponin (cTn) measurements. Within these patients, 945 patients were evaluated by cardiologists, and the incidence of 30-day morality was...
Source: Heart - December 22, 2021 Category: Cardiology Authors: Park, J., Oh, A. R., Lee, S.-H. Tags: Correspondence Source Type: research

Novel bleeding prediction model in atrial fibrillation patients on new oral anticoagulants
Conclusions We present a novel and simple risk score for prediction of major bleeding in patients with non-valvular AF treated with NOACs. Validation in additional cohorts is warranted.
Source: Heart - January 28, 2022 Category: Cardiology Authors: Barnett-Griness, O., Stein, N., Kotler, A., Saliba, W., Gronich, N. Tags: Editor's choice Arrhythmias and sudden death Source Type: research

Single direct oral anticoagulant therapy in stable patients with atrial fibrillation beyond 1 year after coronary stent implantation
Conclusions DOAC monotherapy showed similar efficacy in preventing ischaemic events and was associated with lower major bleeding events compared with combination therapy in patients with AF beyond 1 year after coronary stent implantation.
Source: Heart - January 28, 2022 Category: Cardiology Authors: Choi, Y., Lee, Y., Kim, S.-H., Kim, S., Kim, J. Y., Kim, T.-S., Hwang, Y., Kim, J.-H., Jang, S.-W., Lee, M. Y., Oh, Y.-S. Tags: Coronary artery disease Source Type: research

Atrial fibrillation and risk of incident heart failure with reduced versus preserved ejection fraction
Conclusions AF is associated with both HFrEF and HFpEF events, with no significant difference in the strength of association among these subtypes.
Source: Heart - February 16, 2022 Category: Cardiology Authors: Nicoli, C. D., ONeal, W. T., Levitan, E. B., Singleton, M. J., Judd, S. E., Howard, G., Safford, M. M., Soliman, E. Z. Tags: Arrhythmias and sudden death Source Type: research

Dengue virus infection induces inflammation and oxidative stress on the heart
Conclusions DENV-3 infection induced a marked cardiac dysfunction, which may be associated with inflammation, oxidative stress and electrophysiological changes in the heart. These findings provide new cardiac insights into the mechanisms involved in the pathogenesis triggered by DENV, contributing to the research of new therapeutic targets for clinical practice.
Source: Heart - February 16, 2022 Category: Cardiology Authors: Kangussu, L. M., Costa, V. V., Olivon, V. C., Queiroz-Junior, C. M., Gondim, A. N. S., Melo, M. B., Reis, D., Nobrega, N., Araujo, N., Rachid, M. A., Souza, R. P. d., Tirapelli, C. R., Santos, R. A. S. d., Cruz, J. d. S., Teixeira, M. M., Souza, D. d. G. Tags: Heart failure and cardiomyopathies Source Type: research

Correspondence on 'Omega-3 supplementation and cardiovascular disease: formulation-based systematic review and meta-analysis with trial sequential analysis' by Rizos et al
In their review and meta-analysis, Rizos et al1 reported that omega-3 supplementation at low and higher dosages showed no or weak associations with cardiovascular disease (CVD) outcomes, respectively. More recent reviews also showed protective activity of omega-3 against CVD outcomes. For instance, omega-3 (2–4 g/day) in patients with high or very high triglyceride (TG) levels decreases significantly high-sensitivity C reactive protein (hsCRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), and oxidised low density lipoprotein (LDL)-cholesterol (oxLDL) levels, and the reduction of hsCRP is enhanced when co-admini...
Source: Heart - March 25, 2022 Category: Cardiology Authors: Kountouras, J., Doulberis, M., Kazakos, E., Tzika, S. K., Vardaka, E., Liatsos, C., Papaefthymiou, A. Tags: Correspondence Source Type: research

Cardiac myxomas: clinical presentation, diagnosis and management
Cardiac myxomas (CM) are the most common type of primary cardiac tumours in adults, which have an approximate incidence of up to 0.2% in some autopsy series. The purpose of this review is to summarise the literature on CM, including clinical presentation, differential diagnosis, work-up including imaging modalities and histopathology, management, and prognosis. CM are benign neoplasms developed from multipotent mesenchyme and usually present as an undifferentiated atrial mass. They are typically pedunculated and attached at the fossa ovalis, on the left side of the atrial septum. Potentially life-threatening, the presence ...
Source: Heart - May 12, 2022 Category: Cardiology Authors: Griborio-Guzman, A. G., Aseyev, O. I., Shah, H., Sadreddini, M. Tags: Review articles Reviews Source Type: research