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Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate
Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation and neurodegeneration after stroke, make them promising targets for future drugs. Currently, the ASIC activation mechanism is not understood. Here we used voltage-clamp fluorometry (VCF) combined with fluorophore-quencher pairing to determine the kinetics and direction of movements. We show that conformational changes with the speed of channel activation occur close to the gate and in more distant extracellular sites, where...
Source: eLife - March 17, 2021 Category: Biomedical Science Tags: Neuroscience Structural Biology and Molecular Biophysics Source Type: research

Automatic Classification of the Korean Triage Acuity Scale in Simulated Emergency Rooms Using Speech Recognition and Natural Language Processing: a Proof of Concept Study
CONCLUSION: We demonstrated the potential of an automatic KTAS classification system using speech recognition models, machine learning and BERT-based classifiers.PMID:34254471 | DOI:10.3346/jkms.2021.36.e175
Source: Journal of Korean Medical Science - July 13, 2021 Category: Biomedical Science Authors: Dongkyun Kim Jaehoon Oh Heeju Im Myeongseong Yoon Jiwoo Park Joohyun Lee Source Type: research