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Study on the behavioral changes of a post-stroke depression rat model.
In conclusion, rats with PSD exhibited a significantly reduced memory capacity and altered behavior. The changes in the PSD rats were more severe than those in the rats in the stroke group. PMID: 26170928 [PubMed - as supplied by publisher]
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Dl-3-n-butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal-enriched protein tyrosine phosphatase/ERK/cAMP-response element-binding protein signaling pathway
In conclusion, the present study provided evidence to suggest that the new drug NBP improved amyloid-induced learning and memory deficits, likely through the regulation of the STEP/ERK/CREB pathway. The results revealed that NBP, as a multi-target drug, may exert a neuroprotective effect. Therefore, NBP may serve as an effective treatment for AD.PMID:35350668 | PMC:PMC8943801 | DOI:10.3892/etm.2022.11248
Source: Experimental and Therapeutic Medicine - March 30, 2022 Category: General Medicine Authors: Yan Zhao Wen-Qiang Yang Lu Yu Jing Yang Hai-Rong Zhu Lin Zhang Source Type: research