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Relevance of the cerebral collateral circulation in ischaemic stroke: time is brain, but collaterals set the pace.
Abstract Blood supply to the brain is secured by an extensive collateral circulation system, which can be divided into primary routes, i.e., the Circle of Willis, and secondary routes, e.g., collaterals from the external to the internal carotid artery and leptomeningeal collaterals. Collateral flow is the basis for acute stroke treatment, since neurones will only survive long enough to be rescued with reperfusion therapies if there is sufficient collateral flow. Poor collateral flow is associated with worse outcome and faster growth of larger infarcts in acute stroke treatment. Therapeutic promotion of collateral ...
Source: Swiss Medical Weekly - December 12, 2017 Category: General Medicine Authors: Jung S, Wiest R, Gralla J, McKinley R, Mattle H, Liebeskind D Tags: Swiss Med Wkly Source Type: research

Atrial fibrillation: A moving target.
Abstract Present atrial fibrillation research focuses on three different fields of interest: Basic research to gain a better understanding of the mechanisms leading to atrial fibrillation, epidemiological studies to learn about the time course, the risk factors and the complications of atrial fibrillation, and clinical trials to further improve existing treatment strategies and develop new ones. The focus of this manuscript was the mechanisms, the epidemiology, the diagnosis and the treatment of the arrhythmia per se. Therefore, the field of prevention of stroke and systemic embolism is mostly excluded for the pur...
Source: Swiss Medical Weekly - December 30, 2014 Category: Journals (General) Authors: Eckstein J, Conen D, Kuehne M Tags: Swiss Med Wkly Source Type: research