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In vitro and in  vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury
Abstract PSD‐95 inhibitors have been shown to be neuroprotective in stroke, but have only to a very limited extent been evaluated in the treatment of traumatic brain injury (TBI) that has pathophysiological mechanisms in common with stroke. The aims of the current study were to assess the effects of a novel dimeric inhibitor of PSD‐95, UCCB01‐147, on histopathology and long‐term cognitive outcome after controlled cortical impact (CCI) in rats. As excitotoxic cell death is thought to be a prominent part of the pathophysiology of TBI, we also investigated the neuroprotective effects of UCCB01‐147 and related compou...
Source: European Journal of Neuroscience - December 3, 2016 Category: Neuroscience Authors: Jens Bak Sommer, Anders Bach, Hana Mal á, Kristian Strømgaard, Jesper Mogensen, Darryl S. Pickering Tags: Research Report Source Type: research

In vitro and in vivo effects of a novel dimeric inhibitor of PSD ‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - November 16, 2016 Category: Neuroscience Authors: Jens Bak Sommer, Anders Bach, Hana Mal á, Kristian Strømgaard, Jesper Mogensen, Darryl Scott Pickering Tags: Research Report Source Type: research

Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research