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Source: Behavioural Brain Research
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Total 25 results found since Jan 2013.

A randomized controlled trial of Changes in resting-state functional connectivity associated with short-term motor learning of chopstick use with the non-dominant hand
CONCLUSION]: Offline enhancement of RSFC in these networks was shown to contribute to early chopstick-use motor learning with the left hand. These results serve as a basis for future studies on compensatory networks in individuals with stroke.PMID:37506851 | DOI:10.1016/j.bbr.2023.114599
Source: Behavioural Brain Research - July 28, 2023 Category: Neurology Authors: Sayori Takeda Reiko Miyamoto Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Specific stimulation of PV < sup > + < /sup > neurons at early stage ameliorates prefrontal ischemia-induced spatial working memory impairment
Behav Brain Res. 2021 Aug 3;414:113511. doi: 10.1016/j.bbr.2021.113511. Online ahead of print.ABSTRACTPrefrontal ischemia can cause impairments in learning and memory, executive functions and cognitive flexibility. However, the related cellular mechanisms at the early stage are still elusive. The present study used ischemic stroke in medial prefrontal cortex and systemically investigated the electrophysiological changes of the parvalbumin (PV+) interneurons 12 h post ischemia. We found that Ih and the related voltage sags in PV+ interneurons are downregulated post ischemia, which correlates with hyperpolarization of the me...
Source: Behavioural Brain Research - August 6, 2021 Category: Neurology Authors: Lin Chen Jun Hu Jiankun Mu Chao Li Guang-Yan Wu Chao He Youhong Xie Jian-Ning Ye Source Type: research

Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats.
Abstract Rehabilitation training is routine for children who experience stroke, but its protective mechanism remains unclear. To study the effect of treadmill training intensity on hippocampal synaptic plasticity after cerebral ischemia, a model of middle cerebral artery occlusion (MCAO)/reperfusion was established in young rats to simulate childhood ischemic stroke. The rats were randomly allocated into five groups: sham operation, MCAO, low-intensity exercise and MCAO (5 m/min), medium-intensity exercise and MCAO (10 m/min), and high-intensity exercise and MCAO (15 m/min). Intervention was continued for 14...
Source: Behavioural Brain Research - December 21, 2020 Category: Neurology Authors: Pan G, Cheng J, Shen W, Lin Y, Zhu A, Jin L, Xie Q, Zhu M, Liu C, Tu F, Chen X Tags: Behav Brain Res Source Type: research

Training in a cooperative bimanual skilled reaching task, the popcorn retrieval task, improves unimanual function after motor cortical infarcts in rats.
Abstract Disuse of the paretic hand after stroke is encouraged by compensatory reliance on the nonparetic hand, to exacerbate impairment and potentially constrain motor rehabilitation efficacy. Rodent stroke model findings support that learning new unimanual skills with the nonparetic forelimb diminishes functional improvements that can be driven by rehabilitative training of the paretic forelimb. The influence of learning new ways of skillfully using the two hands together on paretic side function is much less clear. To begin to explore this, we developed a new cooperative bimanual skilled reaching task for rats,...
Source: Behavioural Brain Research - September 13, 2020 Category: Neurology Authors: Dutcher AM, Truong KV, Miller DD, Allred RP, Nudi E, Jones TA Tags: Behav Brain Res Source Type: research

H2S prevents injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module.
Abstract Cerebral ischemia/reperfusion (I/R) injury is a leading cause of learning and memory dysfunction. Hydrogen sulfide (H2S) has been shown to confer neuroprotection in various neurodegenerative diseases, including cerebral I/R-induced hippocampal CA1 injury. However, the underlying mechanisms have not been completely understood. In the present study, rats were pretreated with SAM/NaHS (SAM, an H2S agonist, and NaHS, an H2S donor) only or SAM/NaHS combined with CaM (an activator of CaMKII) prior to cerebral ischemia. The Morris water maze test demonstrated that SAM/NaHS could alleviate learning and memory imp...
Source: Behavioural Brain Research - January 28, 2020 Category: Neurology Authors: Song YJ, Shi Y, Cui M, Li M, Wen XR, Zhou XY, Lou HQ, Wang YL, Qi DS, Tang M, Zhang XB Tags: Behav Brain Res Source Type: research

Differential Effects of Bihemispheric and Unihemispheric Transcranial Direct Current Stimulation in Young and Elderly Adults in Verbal Learning.
In this study, we aimed to explore the impact of bihemispheric and unihemispheric tDCS on verbal learning task performance in two groups (young vs. elderly). Fifteen healthy volunteers participated per group. Each participant received three stimulation conditions: unihemispheric anodal tDCS over the left temporal area, bihemispheric tDCS over the left (anodal) and right (cathodal) temporal areas and a sham condition. During active stimulation, tDCS (20min, 2mA) was applied while each participant learned twenty pseudowords (arbitrarily assigned to corresponding pictures). No significant differences were found between the th...
Source: Behavioural Brain Research - January 2, 2017 Category: Neurology Authors: Fiori V, Nitsche M, Iasevoli L, Cucuzza G, Caltagirone C, Marangolo P Tags: Behav Brain Res Source Type: research

Mapping the dynamics of cortical neuroplasticity of skilled motor learning using micro X-ray fluorescence and histofluorescence imaging of zinc in the rat.
Abstract Synchrotron-based X-ray fluorescence imaging (XFI) of zinc (Zn) has been recently implemented to understand the efficiency of various therapeutic interventions targeting post-stroke neuroprotection and neuroplasticity. However, it is uncertain if micro XFI can resolve neuroplasticity-induced changes. Thus, we explored if learning-associated behavioral changes would be accompanied by changes in cortical Zn concentration measured by XFI in healthy adult rats. Proficiency in a skilled reach-to-eat task during early and late stages of motor learning served as a functional measure of neuroplasticity. c-Fos pro...
Source: Behavioural Brain Research - November 9, 2016 Category: Neurology Authors: Alaverdashvili M, Paterson PG Tags: Behav Brain Res Source Type: research