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Association of clot burden score with radiographic and clinical outcomes following Solitaire stent retriever thrombectomy: analysis of the SWIFT PRIME trial
Conclusions The combination of IV thrombolysis and stent retriever thrombectomy with the Solitaire device is highly effective in achieving successful recanalization and a good clinical outcome throughout the entire range of CBS values.
Source: Journal of NeuroInterventional Surgery - September 12, 2017 Category: Neurosurgery Authors: Mokin, M., Levy, E. I., Siddiqui, A. H., Goyal, M., Nogueira, R. G., Yavagal, D. R., M Pereira, V., Saver, J. L. Tags: Ischemic stroke Source Type: research

E-025 The development of a pre-clinical stroke model for stent-retriever thrombectomy
Conclusion The development of a stroke model amendable to mechanical thrombectomy provides a potential paradigm to study neuroprotection strategies coupled with clinical standard-of-care endovascular treatment. Further reproducibility studies are underway. References . JNIS 2012;4:307–313. . Stroke 2015;46:1099–1106. . AJNR2012;33:353–358. Disclosures O. Brooks: None. R. King: None. J. Chueh: None. M. Marosfoi: None. E. Nossek: 2; C; Rapid Medical. R. Eckhouse: 5; C; Rapid Medical. M. Gedulter: 5; C; Rapid Medical. M. Gounis: 1; C; Rapid Medical.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Brooks, O., King, R., Chueh, J., Marosfoi, M., Nossek, E., Eckhouse, R., Gedulter, M., Gounis, M. Tags: Electronic Poster Abstracts Source Type: research

E-069 Stroke thrombectomy patient selection: sex differences in collateral circulation
Conclusion Although this pilot study did not prove a significant association between poor collateral scores (0-1) and patient sex, there were higher rates of poorer collaterals and lower rates of favorable collaterals among men. Differences in collateral circulation would not appear to explain why women have poorer outcomes after post-thrombectomy, or a clear trend towards poorer collaterals among women would be expected. An analysis of a larger patient sample might yield a stronger association; for now, the sex disparity in stroke functional outcomes among thrombolysed patients remains unclear. Disclosures: K. Keppetipo...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Keppetipola, K., Davison, M., Dua, S., Ouyang, B., Chen, M. Tags: Electronic Poster Abstracts Source Type: research

Balloon-mounted stenting for ICAS in a multicenter registry study in China: a comparison with the WEAVE/WOVEN trial
Conclusions The short-term and long-term outcomes of using a balloon-mounted stent for symptomatic ICAS with focal and non-angular lesions (Mori A and B type) and smooth arterial access were comparable to the results of the WEAVE/WOVEN trial.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Kang, K., Zhang, Y., Shuai, J., Jiang, C., Zhu, Q., Chen, K., Liu, L., Li, B., Shi, X., Gao, L., Liu, Y., Wang, F., Li, Y., Liu, T., Zheng, H., Mo, D., Gao, F., Feng, L., Wang, Y., Wang, Y., Miao, Z., Ma, N., The Study Group of Registry Study of Stenting Tags: Open access, Ischemic stroke Source Type: research

EP61 Direct carotid puncture for mechanical thrombectomy in acute ischaemic stroke: a single centre experience and review of the literature
ConclusionDirect carotid puncture is an effective and generally safe approach for EVT, with major access-site related complications seen in <5% of the cases. It should be considered as a bailout technique or primary access approach in selected cases.ReferencesAkpinar CK, et al. Direct common carotid artery puncture: rescue mechanical thrombectomy strategy in acute ischemic stroke. Neurointervention 2020;15(2):60–66.Cord BJ, et al. Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access. J Neurosurg 2020:1–11.Miszczuk M, et al. Direct puncture of ...
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Chan, J., Cheung, I., Chu, Y., Lee, R. Tags: Treatment Source Type: research

O-033 Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity
ConclusionsThe current study provides novel data on systemic and intracranial VCAM1 in relation to stroke comorbidities, stroke severity, functional outcomes, as well as the role VCAM1 plays in complex protein-protein signaling pathways. These data will allow future studies to develop predictive biomarkers and proteomic targets for drug development to improve our ability to treat a devastating pathology.Disclosures B. Maglinger: None. M. Sands: None. J. Frank: None. C. McLouth: None. A. Trout: None. J. Roberts: None. S. Grupke: None. J. Turchan-Cholewo: None. A. Stowe: None. J. Fraser: None. K. Pennypacker: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Maglinger, B., Sands, M., Frank, J., McLouth, C., Trout, A., Roberts, J., Grupke, S., Turchan-Cholewo, J., Stowe, A., Fraser, J., Pennypacker, K. Tags: Oral abstracts Source Type: research

P-012 Thrombectomy aspiration post-market study in acute stroke: the TAPAS study
ConclusionThe Q Aspiration Catheter is a novel technology that showed comparable deliverability and revascularization rates as other commercially available catheters with no safety concerns. More prospective clinical data is needed to fully assess the Q Aspiration Catheter.AbbreviationsAIS (acute ischemic stroke), MT (mechanical thrombectomy), ASPECTs (Alberta Stroke Program Early CT Score), mTICI (modified TICI score), NIHSS (National Institute of Health Stroke Scale), mRS (modified Rankin Scale), ENT (embolization to a new territory), sICH (symptomatic intracranial hemorrhage)Disclosures F. Ballenilla: 2; C; MIVI Neurosc...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Ballenilla, F., Espinosa, M., Zamarro, J., Masso, J., Garmendia, E., Pumar, J., Larrea, J., Mosqueira, A. Tags: Oral poster abstracts Source Type: research

P-019 Clinical significance of contrast staining after mechanical thrombectomy for acute ischemic stroke
ConclusionContrast staining is associated with the development of ICH, particularly in the early period after MT and worse clinical outcomes. While patients with ICH had worse functional outcomes at discharge, contrast staining itself was not associated with worse outcomes. Lasty, larger diameter clot retriever devices and catheters were not significantly correlated with the presence of contrast staining.Disclosures T. Lazaro: None. P. Cotton: None. C. English: None. K. Katlowitz: None. O. Tanweer: None. D. Raper: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Lazaro, T., Cotton, P., English, C., Katlowitz, K., Tanweer, O., Raper, D. Tags: Oral poster abstracts Source Type: research

P-023 Spoke-administered intravenous alteplase and outcomes for large vessel occlusion stroke patients in a hub-and-spoke telestroke model
ConclusionIn this cohort of 258 patients who first presented to spoke hospitals as potential EVT candidates with CTA-defined ELVO and ASPECTS ≥6, treatment with intravenous alteplase at spoke hospitals before transfer significantly increased the odds of discharge and 90-day functional independence without increasing the odds of ICH. Intravenous alteplase should not be withheld from ELVO patients who first present to spoke hospitals capable of its administration but requiring transfer for EVT. Additional studies are warranted to confirm benefits of spoke-administered alteplase in other hub-and-spoke models and to underst...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Regenhardt, R., Rosenthal, J., Awad, A., Nolan, N., McIntyre, J., Whitney, C., Alotaibi, N., Vranic, J., Stapleton, C., Patel, A., Rost, N., Schwamm, L., Leslie-Mazwi, T. Tags: Oral poster abstracts Source Type: research

P-032 Disparities in stroke: influence of socioeconomic status and race on timely access to mechanical thrombectomy
ConclusionsRace demonstrated to be an independent predictor of timely access to a stroke care facility and mechanical thrombectomy, while SES was not. Additional independent predictors were driving distance, wake-up stroke, and baseline functionality.Disclosures A. V. T. Nguyen: None. G. M Cortez: None. M. Baretta: None. A. Aghaebrahim: 6; C; Advisory board for Rapid Medical. E. Sauvageau: None. R. Hanel: 2; C; Medtronic, Stryker, Cerenovous, Microvention, Balt, Phenox, Rapid Medical, Q’Apel. 4; C; InNeuroCo, Cerebrotech, eLum, Endostream, Three Rivers Medical Inc, Scientia, RisT, BlinkTBI, Corindus. 6; C; advisory b...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Nguyen, A., Cortez, G., Baretta, M., Aghaebrahim, A., Sauvageau, E., Hanel, R. Tags: Oral poster abstracts Source Type: research

E-024 Aspiration thrombectomy on acute ischemic stroke patients with a low alberta stroke program early computerized tomography score
ConclusionEven in AIS patients with low ASPECTS, aspiration thrombectomy treatment can achieve a good functional outcome in some patients and should be considered.Disclosures J. Fifi: 1; C; Microvention, Penumbra, Stryker. 2; C; Microvention, Stryker. 4; C; Imperative Care. A. Hassan: 2; C; GE Healthcare, Genentech, Medtronic, Microvention, Penumbra, Stryker, Cerenovus, Viz.ai, Balt, Scientia. 3; C; GE Healthcare, Genentech, Medtronic, Microvention, Penumbra, Stryker, Cerenovus, Viz.ai, Balt, Scientia. O. Zaidat: 1; C; Genentech, Medtronic Neurovascular, Stryker. 2; C; Codman, Medtronic Neurovascular, National Institutes o...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Fifi, J., Hassan, A., Zaidat, O. Tags: Electronic poster abstracts Source Type: research

E-043 Assessing safety of femoral arterial sheath removal in under 24 hours post-intravascular thrombolysis in stroke patients who undergo mechanical thrombectomy
ConclusionSimilar rates of complications were discovered in both groups of patients, without any significant increase in those whose FAS was removed within 24 hours of tPA administration. Further evaluation should be considered to assess the safety of FAS removal in these patients.Disclosures M. Cohen: None. A. Garg: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Cohen, M., Garg, A. Tags: Electronic poster abstracts Source Type: research

E-092 Mechanical thrombectomy for anterior versus posterior circulation large vessel occlusion stroke: A two-center outcome analysis
ConclusionPosterior circulation LVO mechanical thrombectomy appears safe and effective in judiciously selected patients. The use of a primary aspiration technique and achieving successful revascularization appear fundamental.Disclosures P. Hendrix: None. M. Killer-Oberpfalzer: None. E. Broussalis: None. I. Melamed: None. S. Pikija: None. C. Hecker: None. O. Goren: None. R. Zand: None. C. Schirmer: None. E. Trinka: None. C. Griessenauer: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Hendrix, P., Killer-Oberpfalzer, M., Broussalis, E., Melamed, I., Pikija, S., Hecker, C., Goren, O., Zand, R., Schirmer, C., Trinka, E., Griessenauer, C. Tags: Electronic poster abstracts Source Type: research

E-135 Endovascular treatment of acute extracranial internal carotid artery stroke - Systematic review and pooled analysis of data from the last decade
ConclusionOur systematic review for endovascular treatment of EC-ICA strokes found a high rate of good outcomes and an impressive rate for recanalization, with low mortality rates. Since these results are from observational, retrospective studies, more rigorous randomized trials are required to establish the best approach.Disclosures A. Baig: None. M. Waqas: None. S. Khan: None. A. Monteiro: None. H. Rai: None. R. Dossani: None. J. Cappuzzo: None. F. Almayman: None. J. Davies: 1; C; National Center for Advancing Translational Sciences of the National Institutes of Health under award number KL2TR001413 to the University at ...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Baig, A., Waqas, M., Khan, S., Monteiro, A., Rai, H., Dossani, R., Cappuzzo, J., Almayman, F., Davies, J., Snyder, K., Levy, E., Siddiqui, A. Tags: Electronic poster abstracts Source Type: research

LB-005 The INSIGHT registry: a multi-center, multi-omic stroke clot study, preliminary results
ConclusionThese preliminary results demonstrate the real-world applicability of the INSIGHT study to typical stroke thrombectomy population. Furthermore, the tissue processing protocols are providing high-quality RNA and protein for analysis, which is currently underway.DisclosuresJ. Fraser: 1; C; Penumbra, University of Kentucky. 2; C; Stream Biomedical, Medtronic. 4; C; Cerelux, Fawkes Biotechnology. J. Vicari: None. A. Nanda: None. E. Cheng-Ching: None. K. Woodward: None. B. Rapoport: None. C. Kellner: None.
Source: Journal of NeuroInterventional Surgery - July 29, 2021 Category: Neurosurgery Authors: Fraser, J., Vicari, J., Nanda, A., Cheng-Ching, E., Woodward, K., Rapoport, B., Kellner, C. Tags: Late-breaking oral abstracts Source Type: research

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