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ROCK as a therapeutic target for ischemic stroke.
Authors: Sladojevic N, Yu B, Liao JK Abstract INTRODUCTION: Stroke is a major cause of disability and the fifth leading cause of death. Currently, the only approved acute medical treatment of ischemic stroke is tissue plasminogen activator (tPA), but its effectiveness is greatly predicated upon early administration of the drug. There is, therefore, an urgent need to find new therapeutic options for acute stroke. Areas covered: In this review, we summarize the role of Rho-associated coiled-coil containing kinase (ROCK) and its potential as a therapeutic target in stroke pathophysiology. ROCK is a major regulator of cel...
Source: Expert Review of Neurotherapeutics - October 24, 2017 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence.
Authors: Tsivgoulis G, Safouris A, Krogias C, Arthur AS, Alexandrov AV Abstract Ischemic stroke is a major cause of death and disability and intravenous thrombolysis has been the only approved acute reperfusion therapy (RT) for many years. Seven randomized-controlled clinical trials (RCTs) evaluating the safety and efficacy of endovascular therapy in patients with acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) have been recently published. These studies have changed the treatment paradigm by establishing mechanical thrombectomy (MT) as the most effective acute stroke therapy for improving...
Source: Expert Review of Neurotherapeutics - March 20, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Migraine, low-dose combined hormonal contraceptives, and ischemic stroke in young women: a systematic review and suggestions for future research.
Authors: Ornello R, Canonico M, Merki-Feld GS, Kurth T, Lidegaard Ø, MacGregor EA, Lampl C, Nappi RE, Martelletti P, Sacco S Abstract Introduction. Migraine and combined hormonal contraceptives (CHCs) increase the risk of ischemic stroke in young women; however, the contribution of low-dose (<50 μg ethinylestradiol) CHCs to the risk of ischemic stroke in young women with migraine is not well defined.Areas covered. The authors performed a systematic review of observational studies indexed in PubMed and Scopus from inception to May 22, 2019, reporting the effect sizes of ischemic stroke in women with migraine using...
Source: Expert Review of Neurotherapeutics - February 15, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Monitoring Risk and Preventing Ischemic Stroke in the Very Old
This article examines current guidelines and evidence regarding medical management, lifestyle changes, and psychosocial interactions that can contribute to the primary and secondary prevention of ischemic stroke in the very old.AREAS COVERED: The authors conducted a literature search for ischemic stroke prevention and risk assessment in the elderly via PubMed. Furthermore, they describe current strategies for monitoring risk and preventing ischemic stroke in the elderly population.EXPERT OPINION: Ischemic stroke poses a significant health risk to the elderly, with prevention relying on managing modifiable risk factors such...
Source: Expert Review of Neurotherapeutics - August 4, 2023 Category: Neurology Authors: Mychael Delgardo Grant Rubin Thilan Tudor Anthony J Tang Geoffrey Reeves E Sander Connolly Source Type: research

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