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Source: Stroke
Condition: Atrial Fibrillation

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Total 257 results found since Jan 2013.

Rivaroxaban Versus Dabigatran or Warfarin in Real-World Studies of Stroke Prevention in Atrial Fibrillation Clinical Sciences
Conclusions—In this systematic review and meta-analysis, rivaroxaban was as effective as dabigatran, but was more effective than warfarin for the prevention of stroke/thromboembolism in atrial fibrillation patients. Major bleeding risk was significantly higher with rivaroxaban than with dabigatran, as was all-cause mortality and gastrointestinal bleeding. Rivaroxaban was comparable to warfarin for major bleeding, with an increased risk in gastrointestinal bleeding and decreased risk of intracranial hemorrhage.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Ying Bai, Hai Deng, Alena Shantsila, Gregory Y.H. Lip Tags: Meta Analysis, Quality and Outcomes Original Contributions Source Type: research

Ischemic Stroke in Nonvalvular Atrial Fibrillation at Warfarin Initiation Clinical Sciences
Conclusions—Warfarin effect was qualitatively different in the first 30 days after initiation than subsequently. This is consistent with a modest increase in stroke risk occurring briefly after starting warfarin.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Ping G. Tepper, Xianchen Liu, Melissa Hamilton, Jack Mardekian, William Petkun, Wilson Tan, Daniel E. Singer Tags: Epidemiology Original Contributions Source Type: research

Comparison of Ischemic Stroke Outcomes and Patient and Hospital Characteristics by Race/Ethnicity and Socioeconomic Status Original Contributions
Conclusions— Risk-adjusted inpatient mortality was similar among patients by race/ethnicity but higher among patients from lower income areas. However, this pattern was not evident in sensitivity analyses, including the use of mechanical ventilation as a partial surrogate for stroke severity.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Hanchate, A. D., Schwamm, L. H., Huang, W., Hylek, E. M. Tags: Health policy and outcome research, Acute Cerebral Infarction, Epidemiology Original Contributions Source Type: research

Dabigatran Versus Warfarin: Effects on Ischemic and Hemorrhagic Strokes and Bleeding in Asians and Non-Asians With Atrial Fibrillation Clinical Sciences
Conclusions— Hemorrhagic stroke rates were higher on warfarin in Asians versus non-Asians, despite similar blood pressure, younger age, and lower international normalized ratio values. Hemorrhagic strokes were significantly reduced by DE in both Asians and non-Asians. DE benefits were consistent across Asian and non-Asian subgroups. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00262600.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Hori, M., Connolly, S. J., Zhu, J., Liu, L. S., Lau, C.-P., Pais, P., Xavier, D., Kim, S. S., Omar, R., Dans, A. L., Tan, R. S., Chen, J.-H., Tanomsup, S., Watanabe, M., Koyanagi, M., Ezekowitz, M. D., Reilly, P. A., Wallentin, L., Yusuf, S., the RE-LY In Tags: Other anticoagulants, Embolic stroke Clinical Sciences Source Type: research

Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide Levels for Stroke Risk Prediction in Anticoagulated Patients With Atrial Fibrillation Clinical Sciences
Conclusions— In real-world cohort of anticoagulated patients with AF, NT-proBNP provided complementary prognostic information to an established clinical risk score (CHA2DS2–VASc) for the prediction of stroke/systemic embolism. NT-proBNP was also predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with AF.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Roldan, V., Vilchez, J. A., Manzano-Fernandez, S., Jover, E., Galvez, J., Puche, C. M., Valdes, M., Vicente, V., Lip, G. Y. H., Marin, F. Tags: Arterial thrombosis, Coumarins, Anticoagulants Clinical Sciences Source Type: research

Thrombelastography Detects the Anticoagulant Effect of Rivaroxaban in Patients With Stroke Brief Reports
Conclusions— Thrombelastography can detect the anticoagulant effect of factor Xa inhibitors in patients with stroke and might be useful in the emergency management of those eligible for thrombolysis.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Bowry, R., Fraser, S., Archeval-Lao, J. M., Parker, S. A., Cai, C., Rahbar, M. H., Grotta, J. C. Tags: Coagulation, Thrombin, Platelet function inhibitors Brief Reports Source Type: research

Atrial Fibrillation and Cognitive Decline-The Role of Subclinical Cerebral Infarcts: The Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— The association of incident AF with cognitive decline in stroke-free individuals can be explained by the presence or development of SCIs, raising the possibility of anticoagulation as a strategy to prevent cognitive decline in AF.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Chen, L. Y., Lopez, F. L., Gottesman, R. F., Huxley, R. R., Agarwal, S. K., Loehr, L., Mosley, T., Alonso, A. Tags: Cerebrovascular disease/stroke, Arrhythmias, clinical electrophysiology, drugs, Computerized tomography and Magnetic Resonance Imaging, Epidemiology Clinical Sciences Source Type: research

Risk of Thromboembolic Events in Atrial Fibrillation With Chronic Kidney Disease Clinical Sciences
Conclusions— Impaired renal function is an independent predictor of stroke or systemic embolism in patients with nonvalvular AF. Consideration of renal function may improve stroke risk stratification in patients with AF.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Zeng, W.-T., Sun, X.-T., Tang, K., Mei, W.-Y., Liu, L.-J., Xu, Q., Cheng, Y.-J. Tags: Embolic stroke Clinical Sciences Source Type: research

Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Asian Patients With Nonvalvular Atrial Fibrillation: Meta-Analysis Clinical Sciences
Conclusions— Our findings suggest that standard-dose NOACs were more effective and safer in Asians than in non-Asians, whereas low-dose NOACs performed similarly in both populations.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Wang, K.-L., Lip, G. Y. H., Lin, S.-J., Chiang, C.-E. Tags: Other anticoagulants, Anticoagulants Clinical Sciences Source Type: research

Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) Clinical Sciences
Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00781391.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Rost, N. S., Giugliano, R. P., Ruff, C. T., Murphy, S. A., Crompton, A. E., Norden, A. D., Silverman, S., Singhal, A. B., Nicolau, J. C., SomaRaju, B., Mercuri, M. F., Antman, E. M., Braunwald, E., on behalf of the ENGAGE AF-TIMI 48 Investigators Tags: Atrial Fibrillation, Anticoagulants, Ischemic Stroke Clinical Sciences Source Type: research

Optimal Timing of Anticoagulant Treatment After Intracerebral Hemorrhage in Patients With Atrial Fibrillation Clinical Sciences
Conclusions—This nationwide observational study suggests that anticoagulant treatment may be initiated 7 to 8 weeks after ICH in patients with atrial fibrillation to optimize the benefit from treatment and minimize risk.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Johanna Pennlert, Rosanna Overholser, Kjell Asplund, Bo Carlberg, Bart Van Rompaye, Per-Gunnar Wiklund, Marie Eriksson Tags: Atrial Fibrillation, Anticoagulants, Treatment, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Warfarin Use in Patients With Atrial Fibrillation Undergoing Hemodialysis Clinical Sciences
Conclusions—Our findings suggest that warfarin should be used carefully in hemodialysis patients, given the higher risk of hemorrhagic events and the lack of ability to prevent thromboembolic complications.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Chang-Yun Yoon, Juhwan Noh, Jong Hyun Jhee, Tae Ik Chang, Ea Wha Kang, Youn Kyung Kee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Changsoo Kim, Tae-Hyun Yoo Tags: Arrhythmias, Clinical Studies, Nephrology and Kidney, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation Clinical Sciences
Background and Purpose—The use of oral anticoagulant therapy for stroke prevention in atrial fibrillation has been transformed by the availability of the nonvitamin K antagonist oral anticoagulants. Real-world studies on the use of nonvitamin K antagonist oral anticoagulants would help elucidate their effectiveness and safety in daily clinical practice. Apixaban was the third nonvitamin K antagonist oral anticoagulants introduced to clinical practice, and increasing real-world studies have been published. Our aim was to summarize current evidence about real-world studies on apixaban for stroke prevention in atrial fibril...
Source: Stroke - December 22, 2017 Category: Neurology Authors: Marco Proietti, Imma Romanazzi, Giulio Francesco Romiti, Alessio Farcomeni, Gregory Y.H. Lip Tags: Atrial Fibrillation, Anticoagulants, Quality and Outcomes Original Contributions Source Type: research

Stroke Patients With Suspected Atrial Fibrillation Should NOT Be Started on Anticoagulation WHILE AWAITING the Results of Long-Term Cardiac Monitoring Controversies In Stroke
Source: Stroke - December 24, 2012 Category: Neurology Authors: Katsnelson, M., Sacco, R. L. Tags: Secondary prevention, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Anticoagulants Controversies In Stroke Source Type: research

Awareness of the Role of Atrial Fibrillation as a Cause of Ischemic Stroke Stroke History
Source: Stroke - January 27, 2014 Category: Neurology Authors: Wolf, P. A. Tags: Coumarins, Embolic stroke Stroke History Source Type: research