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Specialty: Hematology
Source: Blood Cells, Molecules and Diseases
Condition: Pain
Therapy: Pain Management
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Total 1 results found since Jan 2013.
Biomarker signatures of sickle cell disease severity.
Abstract
Identifying sickle cell disease patients at high risk of complications could lead to personalized treatment and better prognosis but despite many advances prediction of the clinical course of these patients remains elusive. We propose a system-type approach to discover profiles of multiple, common biomarkers that correlate with morbidity and mortality in sickle cell disease. We used cluster analysis to discover 17 signatures of 17 common circulating biomarkers in 2320 participants of the Cooperative Study of Sickle Cell Disease, and evaluated the association of these signatures with risk for stroke, pain,...
Source: Blood Cells, Molecules and Diseases - May 16, 2018 Category: Hematology Authors: Du M, Van Ness S, Gordeuk V, Nouraie SM, Nekhai S, Gladwin M, Steinberg MH, Sebastiani P Tags: Blood Cells Mol Dis Source Type: research
