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Specialty: Physiology
Condition: Pain
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Total 20 results found since Jan 2013.
Chronic Ablation of TRPV1 Sensitive Skeletal Muscle Afferents Attenuates the Muscle Metaboreflex
Am J Physiol Regul Integr Comp Physiol. 2021 Jul 14. doi: 10.1152/ajpregu.00129.2021. Online ahead of print.ABSTRACTExercise intolerance is a hallmark symptom of cardiovascular disease and likely occurs via enhanced activation of muscle metaboreflex- induced vasoconstriction of the heart and active skeletal muscle which, thereby limits cardiac output and peripheral blood flow. Muscle metaboreflex vasoconstrictor responses occur via activation of metabolite-sensitive afferent fibers located in ischemic active skeletal muscle, some of which express Transient Receptor Potential Vanilloid 1 (TRPV1) cation channels. Local cardi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 14, 2021 Category: Physiology Authors: Joseph Mannozzi Mohamed-Hussein Al-Hassan Beruk Lessanework Alberto Alvarez Danielle Senador Donal S O'Leary Source Type: research
Topical Analgesic Containing Methyl Salicylate and L-Menthol Accelerates Heat Loss During Skin Cooling for Exercise-Induced Hyperthermia
Hyperthermia impairs physical performance and, when prolonged, results in heat stroke or other illnesses. While extensive research has investigated the effectiveness of various cooling strategies, including cold water immersion and ice-suit, there has been little work focused on overcoming the cutaneous vasoconstriction response to external cold stimulation, which can reduce the effectiveness of these treatments. Over-the-counter (OTC) topical analgesics have been utilized for the treatment of muscle pain for decades; however, to date no research has examined the possibility of taking advantage of their vasodilatory functi...
Source: Frontiers in Physiology - July 13, 2022 Category: Physiology Source Type: research
Habituation of the stress response multiplex to repeated cold pressor exposure
Humans show remarkable habituation to aversive events as reflected by changes of both subjective report and objective measures of stress. Although much experimental human research focuses on the effects of stress, relatively little is known about the cascade of physiological and neural responses that contribute to stress habituation. The cold pressor test (CPT) is a common method for inducing acute stress in human participants in the laboratory; however, there are gaps in our understanding of the global state changes resulting from this stress-induction technique and how these responses change over multiple exposures. Here...
Source: Frontiers in Physiology - January 10, 2023 Category: Physiology Source Type: research
Effects of exercise induced muscle damage on cardiovascular responses to isometric muscle contractions and post-exercise circulatory occlusion
ConclusionThe MAP correlations with muscle soreness, RPE and Pain during contractions of damaged muscles suggests that higher afferent activity was associated with higher MAP responses to exercise.
Source: European Journal of Applied Physiology - June 27, 2023 Category: Physiology Source Type: research
