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Contribution of Maladaptive Adipose Tissue Expansion to Development of Cardiovascular Disease.
Authors: Jia G, Jia Y, Sowers JR Abstract The overweight and obesity epidemic has led to an increase in the metabolic syndrome and associated cardiovascular disease (CVD). These abnormalities include insulin resistance, type 2 diabetes mellitus, vascular stiffness, hypertension, stroke, and coronary heart disease. Visceral white adipocyte tissue (WAT) expansion and associated fibrosis/stiffness of WAT promote insulin resistance and CVD through increases in proinflammatory adipokines, oxidative stress, activation of renin-angiotensin-aldosterone system, dysregulation of adipocyte apoptosis and autophagy, dysfunction...
Source: Comprehensive Physiology - February 1, 2017 Category: Physiology Tags: Compr Physiol Source Type: research

Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction.
This article aims to discuss the current understanding of the diagnosis and pathophysiology of PE, as well as associated organ damage, maternal and fetal outcomes, and potential therapeutic avenues. © 2021 American Physiological Society. Compr Physiol 11:1315-1349, 2021. PMID: 33295016 [PubMed - in process]
Source: Comprehensive Physiology - December 11, 2020 Category: Physiology Tags: Compr Physiol Source Type: research

Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research

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