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Total 267 results found since Jan 2013.

Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research

Cardiovascular Outcomes in Sleep-Disordered Breathing: Are We Under-estimating?
Obstructive sleep apnea is a growing health concern, affecting nearly one billion people worldwide; increasingly recognized as an independent cardiovascular risk factor associated with incident obesity, insulin resistance, hypertension, arrhythmias, stroke, coronary artery disease, and heart failure. The prevalence of obstructive sleep apnea could be underestimated in the previous studies, leading to only modest predictions of cardiovascular outcomes. Using more physiologic data will increase sensitivity for the diagnosis of obstructive sleep apnea. Individuals at high risk of obstructive sleep apnea should be identified s...
Source: Frontiers in Neurology - March 15, 2022 Category: Neurology Source Type: research

Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research