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Surgical ablation in hypertrophic obstructive cardiomyopathy: What is the real deal?
Atrial fibrillation (AF) is the most common tachyarrhythmia in patients with hypertrophic obstructive cardiomyopathy (HOCM), with an estimated prevalence of approximately 20% [1]. AF is associated with malignant outcomes in patients with HOCM, with an increased risk of embolic stroke, heart failure, severe functional impairment and mortality [2]. Furthermore, AF is poorly tolerated by patients with HOCM, with increased heart failure episodes, hemodynamic instability and impaired quality of life [3].
Source: International Journal of Cardiology - July 8, 2023 Category: Cardiology Authors: Alessandra Sala, Ottavio Alfieri Tags: Editorial Source Type: research

The role of adrenomedullin in acute coronary syndrome
In the study published by IJC [1] 7 circulating biomarkers related to hemostasis and fibrinolytic pathways, endothelial function and vascular regulation were analyzed in a cohort of 1370 patients with acute coronary syndrome. Moreover, their association with outcome of re-admission due to myocardial infarction, ischemic stroke, heart failure or death were assessed. Interestingly, their predictive value for outcome in relation to renal function was also determined. Chronic kidney disease patients have a well-known increased cardiovascular risk and have worse outcome after an acute coronary syndrome.
Source: International Journal of Cardiology - February 6, 2023 Category: Cardiology Authors: Roberto G. Carbone, Francesco Puppo Tags: Editorial Source Type: research

The dilemma of thromboembolism prophylaxis in patient with acute heart failure
Despite advances in treatment, heart failure (HF) continues to be associated with high morbidity and mortality [1]. One of the reasons for this fact is the thrombogenicity seen in these patients through different mechanisms (Fig. 1) via Virchow's triad: blood stasis, endothelial dysfunction, and hypercoagulability; resulting in reported rates of up to 30% of venous thromboembolism (VTE), stroke, and sudden death among HF patients [2]. On the other hand, atrial fibrillation (AF) frequently coexists increasing the risk of thromboembolic events, and while the efficacy of anticoagulants in this last population has been proven ...
Source: International Journal of Cardiology - December 16, 2022 Category: Cardiology Authors: H. Amparo Taveras Tags: Editorial Source Type: research

Betablockers reduce oxygen pulse increase and performance in heart failure patients with preserved ejection fraction
Beta blockers (BB) reduce chronotropic response and exercise capacity in heart failure with preserved ejection fraction (HFpEF). To analyze the influence of BB on exercise performance and O 2 pulse increase as a surrogate for stroke volume in HFpEF.
Source: International Journal of Cardiology - October 8, 2022 Category: Cardiology Authors: Wernhart Simon, Papathanasiou Maria, Amir Abbas Mahabadi, Rassaf Tienush, Luedike Peter Source Type: research

Differential cardiovascular and renal benefits of SGLT2 inhibitors and GLP1 receptor agonists in patients with type 2 diabetes mellitus
Background:The differential benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) in cardiovascular or renal outcomes have not been fully investigated.Methods: Patients with diabetes prescribed SGLT2i or GLP1RA were retrospectively identified. Patients treated with antihyperglycemic medications other than SGLT2i or GLP1RA were used as a control group. Primary outcomes were composite ischemic events (acute coronary syndrome, coronary revascularization, and stroke) and a composite of heart failure and renal events (hospitalization for heart failure, renal death,...
Source: International Journal of Cardiology - June 14, 2022 Category: Cardiology Authors: Chee Hae Kim, In-Chang Hwang, Hong-Mi Choi, Chang Ho Ahn, Yeonyee E. Yoon, Goo-Yeong Cho Source Type: research

Assessment of atrial function by echocardiography: Can this be used to assess the arrhythmogenic atrial substrate?
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. It is associated with a high risk for thromboembolic stroke, heart failure, decreased quality of life and cognitive impairment, all increasing mortality. After confirmation of AF, comprehensive assessment of i) stroke risk, ii) symptom severity, iii) severity of AF-burden and iv) atrial substrate severity is recommended in accordance with the 4S-AF scheme proposed by the current European AF-guidelines to provide optimal treatment for the individual patient [1].
Source: International Journal of Cardiology - June 1, 2022 Category: Cardiology Authors: Florian Bruns, Dobromir Dobrev Tags: Editorial Source Type: research

Poor oral health: Cause or risk factor for future cardiovascular diseases
In this issue of the International Journal of Cardiology, Matsui et al. investigated the association between daily toothbrushing behavior and future cardiovascular (CV) events, including CV-death, myocardial infarction (MI), hospitalization for heart failure (HF) and stroke, in 692 participants during a median follow-up of 28  months [1]. This prospective study showed that group of subjects with poor oral hygiene (who brushed their teeth
Source: International Journal of Cardiology - February 9, 2022 Category: Cardiology Authors: Srdjan Aleksandric Tags: Editorial Source Type: research

Screening for atrial fibrillation: If I was left to my own devices
Atrial fibrillation (AF) is established as the most prevalent clinical arrhythmia, and a major risk factor for stroke, death, heart failure, cognitive decline, and hospitalisation [1]. Ranking these complications is difficult, however ischemic stroke caused by AF is posing a significant burden to patients, their next of kin, to physicians and to the health care system. The stroke risk in AF patients can be markedly lowered by oral anticoagulation (OAC) treatment [2], but many patients with AF have few or no symptoms [3], hence health care contacts and arrhythmia detection might be lacking [4].
Source: International Journal of Cardiology - November 16, 2021 Category: Cardiology Authors: Emma Svennberg, Johan Engdahl Tags: Editorial Source Type: research

Proteomic profiles of patients with atrial fibrillation provide candidate biomarkers for diagnosis
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide with an increasing risk of heart failure, stroke, and thromboembolic events. Currently distinct pathophysiological mechanisms during AF development and valuable biomarkers for AF management remain unknown.
Source: International Journal of Cardiology - September 27, 2021 Category: Cardiology Authors: WeiYi Zhong, Hui Yang, YuLin Wang, Ye Yang, ChangFa Guo, ChunSheng Wang, Qiang Ji Source Type: research

Diastolic dysfunction in women with ischemia and non-obstructive coronary arteries (INOCA) – Could non-invasive imaging reveal the missing piece of puzzle?
A large proportion of patients with chronic coronary syndromes will not have obstructive coronary artery disease (CAD) on invasive coronary angiography, more often women than men [1]. Ischemia with non-obstructive coronary arteries (INOCA), once considered a benign condition, is now recognized to be associated with increased risk of adverse events, including heart failure (HF), myocardial infarction, stroke and cardiovascular death as well as increased number of hospitalizations [2 –5]. Among INOCA patients, those with evidence of both coronary microvascular and diastolic dysfunction seem to bear the highest risk of adve...
Source: International Journal of Cardiology - April 16, 2021 Category: Cardiology Authors: Anca Florian Tags: Editorial Source Type: research

Impact of History of Depression on 1-Year Outcomes in Patients with Chronic Coronary Syndromes: An Analysis of a Contemporary, Prospective, Nationwide Registry
Background. Depression is common in patients with acute cardiovascular conditions and it is associated with adverse clinical events.Methods. Using the data from a nationwide, prospective registry on patients with chronic coronary syndromes (CCS), we assessed the impact of depression on major adverse cardiovascular events (MACE), a composite of all-cause death and hospitalization for myocardial infarction, revascularization, heart failure or stroke, and quality of life (QoL) at 1-year follow-up.Results.
Source: International Journal of Cardiology - January 7, 2021 Category: Cardiology Authors: Luca, Pier Luigi Temporelli, Antonio Francesco Amico, Lucio Gonzini, Massimo Uguccioni, Elisabetta Varani, Natale Daniele Brunetti, Furio Colivicchi, Domenico Gabrielli, Michele Massimo Gulizia Source Type: research

Revascularisation therapies improve the outcomes of ischemic stroke patients with atrial fibrillation and heart failure
Atrial fibrillation (AF) and heart failure (HF) carry a poor prognosis in acute ischaemic stroke (AIS). The impact of revascularisation therapies on outcomes in these patients is not fully understood.
Source: International Journal of Cardiology - October 1, 2020 Category: Cardiology Authors: Tiberiu A. Pana, Mohamed O. Mohamed, Allan B. Clark, Eoin Fahy, Mamas A. Mamas, Phyo K. Myint Source Type: research

Determinants of outcome in patients with heart failure with reduced ejection fraction & secondary mitral regurgitation
The outcome of secondary mitral regurgitation (MR) in patients with heart failure is poor. Survival is related to the severity of MR. We sought to investigate the effect of left ventricular contractility, the ratio of left ventricular end-diastolic volume (LVEDV) to effective orifice area (EROA) and the ratio of regurgitant volume (RVol) to stroke volume (SV) on cardiovascular survival.
Source: International Journal of Cardiology - September 6, 2020 Category: Cardiology Authors: Athina Chasapi, Nikos Karogiannis, Spyridon Zidros, Kush Patel, Guy Lloyd, Sanjeev Bhattacharyya Source Type: research

The hospitalizations in hypertrophic cardiomyopathy: “the dark side of the moon”.
Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left ventricular hypertrophy not solely explainable by abnormal loading condition [1,2]. Patients with HCM show a different clinical course, ranging from an asymptomatic status, with no adverse events and normal or extended longevity, to a symptomatic condition in which several disease complications can occur [3]. Among HCM patients which experience disease progression, 3 different pathways have been identified: refractory heart failure (HF), requiring surgical myectomy/alcohol ablation (obstructive HCM, OHCM) or heart transplant (non-obstructive HC...
Source: International Journal of Cardiology - August 14, 2020 Category: Cardiology Authors: Emanuele Monda, Giuseppe Limongelli Tags: Editorial Source Type: research

The hospitalizations in hypertrophic cardiomyopathy: “The dark side of the moon”
Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left ventricular hypertrophy not solely explainable by abnormal loading condition [1,2]. Patients with HCM show a different clinical course, ranging from an asymptomatic status, with no adverse events and normal or extended longevity, to a symptomatic condition in which several disease complications can occur [3]. Among HCM patients which experience disease progression, 3 different pathways have been identified: refractory heart failure (HF), requiring surgical myectomy/alcohol ablation (obstructive HCM, OHCM) or heart transplant (non-obstructive HC...
Source: International Journal of Cardiology - August 14, 2020 Category: Cardiology Authors: Emanuele Monda, Giuseppe Limongelli Tags: Editorial Source Type: research

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