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Glucose lowering does not necessarily reduce cardiovascular risk in type 2 diabetes
World J Cardiol. 2022 Apr 26;14(4):266-270. doi: 10.4330/wjc.v14.i4.266.ABSTRACTDiabetes mellitus (DM) is a health condition characterized by glucose dysregulation and affects millions of people worldwide. The presentation of heart failure in diabetic cardiomyopathy extends over a wide phenotypic spectrum, commencing from asymptomatic, subclinical structural abnormalities to severely symptomatic biventricular dysfunction with increased mortality risk. Similarly, the spectrum of systolic dysfunction in diabetic-induced heart failure is diverse. DM leads also to cardiac electrical remodeling reacting on various targets. Dipe...
Source: World Journal of Cardiology - May 18, 2022 Category: Cardiology Authors: Angeliki Bourazana Grigorios Giamouzis John Skoularigis Filippos Triposkiadis Andrew Xanthopoulos Source Type: research

Heart failure with reduced, mildly reduced, or preserved left ventricular ejection fraction: Has reasoning been lost?
World J Cardiol. 2022 Jul 26;14(7):438-445. doi: 10.4330/wjc.v14.i7.438.ABSTRACTLeft ventricular (LV) ejection fraction (LVEF), defined as LV stroke volume divided by end-diastolic volume, has been systematically used for the diagnosis, classification, and management of heart failure (HF) over the last three decades. HF is classified as HF with reduced LVEF, HF with midrange or mildly reduced LVEF, and HF with preserved LVEF using arbitrary, continuously changing LVEF cutoffs. A prerequisite for using this LVEF-based terminology is knowledge of the LVEF normal range, which is lacking and may lead to erroneous conclusions i...
Source: World Journal of Cardiology - September 26, 2022 Category: Cardiology Authors: Andrew Xanthopoulos Grigorios Giamouzis John Skoularigis Filippos Triposkiadis Source Type: research

Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age
CONCLUSION: aTRH was significantly associated with an increased risk of CVD and this association was modified by both sex and age. Further studies are warranted to test these mechanisms.PMID:37274374 | PMC:PMC10237003 | DOI:10.4330/wjc.v15.i5.262
Source: World Journal of Cardiology - June 5, 2023 Category: Cardiology Authors: Julianne Theresa Nelson Longjian Liu Source Type: research

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