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Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors: A meta-analysis of cardiovascular outcome trials
CONCLUSION: DPP-4 inhibitors do not seem to confer any significant cardiovascular benefit for patients with T2DM, while they do not seem to be associated with a significant risk for any major cardiac arrhythmias, except for atrial flutter. Therefore, this drug class should not be the treatment of choice for patients with established cardiovascular disease or multiple risk factors, except for those cases when newer antidiabetics (glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors) are not tolerated, contraindicated or not affordable for the patient.PMID:34754403 | PMC:PMC8554356 | DOI:1...
Source: World Journal of Cardiology - November 10, 2021 Category: Cardiology Authors: Dimitrios Ioannis Patoulias Aristi Boulmpou Eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos Source Type: research

BLEED-Myocardial Infarction Score: Predicting mid-term post-discharge bleeding events.
CONCLUSION: A new bedside prediction-scoring model for post-discharge mid-term bleeding has been derived and preliminarily validated. This is the first score designed to predict mid- term hemorrhagic risk in patients discharged following admission for acute MI. This model should be externally validated in larger cohorts of patients before its potential implementation. PMID: 23802048 [PubMed - as supplied by publisher]
Source: World Journal of Cardiology - June 26, 2013 Category: Cardiology Authors: Barra S, Providência R, Caetano F, Almeida I, Paiva L, Dinis P, Leitão Marques A Tags: World J Cardiol Source Type: research

Effective treatment of depression improves post-myocardial infarction survival.
CONCLUSION: The analysis of TRD in the ENRICHD study shows that the effective treatment of depression reduced mortality in depressed post-MI patients. It is important to monitor the effectiveness of depression treatment and change treatments if necessary to reduce depression and improve cardiac outcomes in depressed post-MI patients. PMID: 25914790 [PubMed]
Source: World Journal of Cardiology - April 26, 2015 Category: Cardiology Authors: Banankhah SK, Friedmann E, Thomas S Tags: World J Cardiol Source Type: research

Does heart rate variability correlate with long-term prognosis in myocardial infarction patients treated by early revascularization?
CONCLUSION: In our group of patients with a recent complicated MI, abnormal autonomic parameters have been found with a prevalence that was similar for STEMI and NSTEMI cases, and substantially unchanged in comparison to what reported in the pre-primary-PCI era. Long-term outcomes did not correlate with level of depression of HRV parameters recorded in the subacute phase of the disease, both in STEMI and in NSTEMI patients. These results support lack of prognostic significance of traditional HRV parameters when immediate coronary reperfusion is utilised. PMID: 28163834 [PubMed - in process]
Source: World Journal of Cardiology - January 25, 2017 Category: Cardiology Authors: Compostella L, Lakusic N, Compostella C, Truong LV, Iliceto S, Bellotto F Tags: World J Cardiol Source Type: research

Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction.
CONCLUSION: Adrenal βarrestin1 upregulation is one of the mechanisms by which tobacco compounds, like nicotine, promote cardio-toxic hyperaldosteronism in vitro and in vivo. Thus, adrenal βarrestin1 represents a novel therapeutic target for tobacco-related heart disease prevention or mitigation. PMID: 32547713 [PubMed]
Source: World Journal of Cardiology - May 25, 2020 Category: Cardiology Authors: Cora N, Ghandour J, Pollard CM, Desimine VL, Ferraino KE, Pereyra JM, Valiente R, Lymperopoulos A Tags: World J Cardiol Source Type: research

Climatic influences on cardiovascular diseases
World J Cardiol. 2022 Mar 26;14(3):152-169. doi: 10.4330/wjc.v14.i3.152.ABSTRACTClassical risk factors only partially account for variations in cardiovascular disease incidence; therefore, also other so far unknown features, among which meteorological factors, may influence heart diseases (mainly coronary heart diseases, but also heart failure, arrhythmias, aortic dissection and stroke) rates. The most studied phenomenon is ambient temperature. The relation between mortality, as well as cardiovascular diseases incidence, and temperature appears graphically as a ''U'' shape. Exposure to cold, heat and heat waves is associat...
Source: World Journal of Cardiology - April 18, 2022 Category: Cardiology Authors: Maurizio Giuseppe Abrignani Alberto Lombardo Annabella Braschi Nicol ò Renda Vincenzo Abrignani Source Type: research

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