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Screening for Asymptomatic Atrial Fibrillation While Monitoring the Blood Pressure at Home: Trial of Regular Versus Irregular Pulse for Prevention of Stroke (TRIPPS 2.0)
In conclusion, home screening for asymptomatic AF while taking BP measurements can be performed accurately. This can be used to detect new AF, allowing treatment with anticoagulation to reduce the future risk for stroke.
Source: The American Journal of Cardiology - March 18, 2013 Category: Cardiology Authors: Joseph Wiesel, Saji Abraham, Frank C. Messineo Tags: Arrhythmias and Conduction Disturbances Source Type: research

Relation Between Preoperative Renal Dysfunction and Cardiovascular Events (Stroke, Myocardial Infarction, or Heart Failure or Death) Within Three Months of Isolated Coronary Artery Bypass Grafting
Renal dysfunction is related to long-term mortality and myocardial infarction after coronary artery bypass grafting (CABG). We aimed to investigate the association between preoperative renal dysfunction and early risk of stroke, myocardial infarction, or heart failure after CABG. From the Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry, we included all 36,284 patients who underwent primary isolated CABG from 2000 to 2008 in Sweden. The Swedish National Inpatient Registry was used to obtain the primary end point, which was rehos...
Source: The American Journal of Cardiology - July 18, 2013 Category: Cardiology Authors: Martin J. Holzmann, Ulrik Sartipy Tags: Coronary Artery Disease Source Type: research

Risk of Stroke in Older Adults With Heart Failure
Heart failure (HF) is a risk factor for incident stroke. However, less is known about the independent nature of this association and to what extent various baseline characteristics may mediate this risk. Of the 5,795 community-dwelling adults aged ≥65 years in the Cardiovascular Health Study, 5,448 were free of baseline stroke, of whom 229 had baseline HF. We used a multivariable-adjusted Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for centrally adjudicated incident stroke associated with HF.
Source: The American Journal of Cardiology - December 10, 2022 Category: Cardiology Authors: Elizabeth Bierbower, Nayrana Griffith, Venkatesh K. Raman, Vijaywant Brar, Jeffrey Roseman, Prakash Deedwania, Gregg C. Fonarow, Richard M. Allman, Charles Faselis, Sijian Zhang, George Howard, Ali Ahmed, Phillip H. Lam Source Type: research

The CHA2DS2-VASc Score for Risk Stratification of Stroke in Heart Failure With-vs-Without Atrial Fibrillation
A recent study suggested that the CHA2DS2-VASc score can risk stratify heart failure (HF) patients without atrial fibrillation (AF) for stroke. We performed a retrospective analysis using the national Veteran Affairs database to externally validate the findings. Crude incidence rates of end points were calculated. A Cox proportional model was used to study the association between the CHA2DS2-VASc score and outcomes. In HF patients with AF (n  = 17,481) and without AF (n = 36,935), the 1 year incidence rate for ischemic stroke, thromboembolism, thromboembolism (without MI), and death were 2.7 and 2.0%; 10.3 and 7.9%; 4....
Source: The American Journal of Cardiology - July 14, 2021 Category: Cardiology Authors: George R. Marzouka, Harold Rivner, Vijay Mehta, Juan Lopez, Igor Vaz, Fei Tang, Hemant Ishwaran, Jeffrey J. Goldberger Source Type: research

Atrial Myopathy and Ischemic Stroke in Heart Failure With Preserved Ejection Fraction
We examined the hypothesis that atrial myopathy may be associated with ischemic stroke in patients with heart failure with preserved ejection fraction. This is an exploratory, post hoc analysis of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. Patients with sinus rhythm documented at baseline electrocardiogram and without known AF were included in this analysis.
Source: The American Journal of Cardiology - July 27, 2023 Category: Cardiology Authors: Kassem Farhat, Khaled Elkholey, Zain Ul Abideen Asad, Stavros Stavrakis Source Type: research

Influence of Left Ventricular Stroke Volume on Incident Heart Failure in a Population with Preserved Ejection Fraction (From the Strong Heart Study)
At a given level of left ventricular (LV) systolic function, LV pump performance (assessed by stroke index [SVi]) may differ, depending on LV size. We evaluated whether low SVi may be considered a marker of risk for incident congestive heart failure (HF), independent of LV geometry and systolic function, assessed by ejection fraction (EF) or midwall fractional shortening (MFS), in a large population-based sample with normal EF. Clinical and echocardiographic data from the second Strong Heart Study (SHS) exam, including 2,885 American Indians (59 ±8 years; 63% women) with normal EF (EF≥51% in men and EF≥55% in women) a...
Source: The American Journal of Cardiology - January 4, 2017 Category: Cardiology Authors: Marina De Marco, Eva Gerdts, Costantino Mancusi, Mary J. Roman, Mai Tone L ønnebakken, Elisa T. Lee, Barbara V. Howard, Richard B. Devereux, Giovanni de Simone Source Type: research

Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality of Life Scores in Patients with Heart Failure (From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation ORBIT-AF)
This study aimed to determine the impact of heart failure (HF) on clinical outcomes in patients with atrial fibrillation (AF). We analyzed data from ORBIT-AF, a national registry of 10,135 AF patients to determine associations between HF as well as left ventricular ejection fraction (LVEF) and outcomes, including stroke, mortality, and hospitalization using Cox multivariable modeling.
Source: The American Journal of Cardiology - March 14, 2017 Category: Cardiology Authors: Tharian S. Cherian, Peter Shrader, Gregg C. Fonarow, Larry A. Allen, Jonathan P. Piccini, Eric D. Peterson, Laine Thomas, Peter R. Kowey, Bernard J. Gersh, Kenneth W. Mahaffey Source Type: research

Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life Scores in Patients With Heart Failure (from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation ORBIT-AF)
This study aimed to determine the impact of HF on clinical outcomes in patients with AF. We analyzed data from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, a national registry of 10,135 patients with AF to determine associations between HF and left ventricular ejection fraction (LVEF) and outcomes, including stroke, mortality, and hospitalization using Cox multivariable modeling.
Source: The American Journal of Cardiology - March 15, 2017 Category: Cardiology Authors: Tharian S. Cherian, Peter Shrader, Gregg C. Fonarow, Larry A. Allen, Jonathan P. Piccini, Eric D. Peterson, Laine Thomas, Peter R. Kowey, Bernard J. Gersh, Kenneth W. Mahaffey Tags: Arrhythmias and Conduction Disturbances Source Type: research

Prediction of Incident Atrial Fibrillation According to Gender in Patients with Ischemic Stroke From a Nationwide Cohort
The CHA2DS2-VASc score may identify patients at higher risk of atrial fibrillation (AF) following ischemic stroke (IS) among patients without known AF. We compared gender-related differences in items from CHA2DS2-VASc score and their relationship with AF occurrence after IS. This French cohort study was based on the database covering hospital care from 2009 to 2012 for the entire population. Of 336,291 patients with IS, 240,459 (71.5%) had no AF at baseline. Women were older, more frequently had hypertension, heart failure, and had a higher CHA2DS2-VASc score than men (4.63 vs 4.39, p
Source: The American Journal of Cardiology - November 30, 2017 Category: Cardiology Authors: Arnaud Bisson, Alexandre Bodin, Nicolas Clementy, Dominique Babuty, Gregory Y.H. Lip, Laurent Fauchier Source Type: research

Medication-taking Behaviors and Perceptions Among Adults with Heart Failure (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
We examined medication-taking behaviors and perceptions among individuals with HF with a particular focus on BBs. A mailed survey on medication use was administered to US adults with HF enrolled in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Source: The American Journal of Cardiology - February 23, 2019 Category: Cardiology Authors: Matthew T. Mefford, Alysse Sephel, Melissa K. Van Dyke, Ligong Chen, Raegan W. Durant, Todd M. Brown, Matthew Fifolt, Juan Maya, Parag Goyal, Monika M. Safford, Emily B. Levitan Source Type: research

Stroke and Systemic Embolism and other Adverse Outcomes of Heart Failure with Preserved and Reduced Ejection Fraction in Patients with Atrial Fibrillation (From the COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation CODE-AF)
It is unknown whether heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) carry a similar risk of stroke or systemic embolism (SE) and other outcomes in patients with non-valvular atrial fibrillation (AF). A prospective, multicenter outpatient registry with echocardiographic data which enrolled 10,589 patients from June 2016 to May 2019 was analyzed. In this registry, 935 (8.8%) patients had HF, and the proportions of patients with HFpEF and HFrEF were 43.2% and 56.8%, respectively.
Source: The American Journal of Cardiology - October 9, 2019 Category: Cardiology Authors: Seyong Chung, Tae-Hoon Kim, Jae-Sun Uhm, Myung-Jin Cha, Jung-Myung Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jun Kim, Hyung Wook Park, Eue-Keun Choi, Jin-Bae Kim, Chang-Soo Kim, Young Soo Lee, Jaemin Shim, Boyoung Joung Source Type: research

Comparison of the CHA2DS2-VASc, CHADS2, HAS-BLED, ORBIT, and ATRIA Risk Scores in Predicting Non –Vitamin K Antagonist Oral Anticoagulants-Associated Bleeding in Patients With Atrial Fibrillation
The increasing adoption of non –vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation (AF) necessitates a reassessment of bleeding risk scores. Because known risk factors for bleeding are largely the same as for stroke, we hypothesize that stroke risk scores could also be used to identify patients with high bleeding risks. We aimed to compare the performance of 2 stroke risk scores (Congestive Heart failure, hypertension, Age ≥75 [doubled], Diabetes, Stroke [doubled], Vascular disease, Age 65–74, and Sex [female] [CHA2DS2-VASc] and Cardiac failure, Hypertension, Age, Diabetes, ...
Source: The American Journal of Cardiology - July 31, 2017 Category: Cardiology Authors: Xiaoxi Yao, Bernard J. Gersh, Lindsey R. Sangaralingham, David M. Kent, Nilay D. Shah, Neena S. Abraham, Peter A. Noseworthy Source Type: research

Effects of Valsartan Versus Amlodipine in Diabetic Hypertensive Patients With or Without Previous Cardiovascular Disease
In conclusion, the ARB- and the CCB-based treatments exerted similar protective effects of CVD events regardless of the presence of previous CVD. For stroke events, the ARB may have more protective effects than the CCB in diabetic hypertensive patients with previous CVD.
Source: The American Journal of Cardiology - September 16, 2013 Category: Cardiology Authors: Kentaro Yamashita, Takahisa Kondo, Takashi Muramatsu, Kunihiro Matsushita, Takanori Nagahiro, Kengo Maeda, Satoshi Shintani, Toyoaki Murohara Tags: Systemic Hypertension Source Type: research

Risk of Sudden Death and Outcome in Patients With Hypertrophic Cardiomyopathy With Benign Presentation and Without Risk Factors
In conclusion, in patients with HC without conventional risk factors and with no or mild symptoms, the risk of sudden death was not negligible, with an event rate of 0.6% per year. Heart failure and stroke-related death were less common and largely confined to older patients. These results underscore the need for a more accurate assessment of the sudden death risk in patients with HC.
Source: The American Journal of Cardiology - February 14, 2014 Category: Cardiology Authors: Paolo Spirito, Camillo Autore, Francesco Formisano, Gabriele Egidy Assenza, Elena Biagini, Tammy S. Haas, Sergio Bongioanni, Christopher Semsarian, Emmanuela Devoto, Beatrice Musumeci, Francesco Lai, Laura Yeates, Maria Rosa Conte, Claudio Rapezzi, Luca B Tags: Cardiomyopathy Source Type: research

Anticoagulant Agents for Atrial Fibrillation in Cancer Patients
In a recent article in the journal, Patell et  al1 found CHADS2 (congestive heart failure, hypertension, age ≥ 75, diabetes mellitus, prior stroke/transient ischemic attack/thromboembolism) and CHA2DS2VASC (congestive heart failure, hypertension, age ≥ 75, diabetes mellitus, prior stroke/transient ischemic attack/thromboembolism, vascular disease, age 65-74, sex category [i.e., female]) to predict risk of ischemic stroke in cancer patients with baseline atrial fibrillation (AF). Although only 36% of patients received anticoagulant therapy, the risk of stroke generally appeared to be lower than in cancer-free individuals.
Source: The American Journal of Cardiology - February 3, 2018 Category: Cardiology Authors: Marc Sorigue, Edurne Sarrate, Mireia Franch-Sarto, Mireia Santos-Gomez, Elisa Orna Source Type: research

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