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Adiponectin: a relevant player in obesity-related colorectal cancer?
Obesity is a condition characterised by an abnormally elevated mass of body fat. The past decades have seen a dramatic rise in the worldwide incidence of obesity due to lifestyle changes that have led to an overall reduced physical activity and an increase in the intake of excessive and/or highly caloric or processed foods. As a consequence, obesity represents nowadays a major global health concern. In particular, several epidemiological studies have linked obesity to a shortened lifespan due primarily to a higher risk for the development of chronic pathologies that include cardiovascular complications such as high blood p...
Source: Gut - February 28, 2013 Category: Gastroenterology Authors: Cava, A. L. Tags: Commentary Source Type: research

Legumain is Activated in Macrophages during Pancreatitis.
Abstract Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated activity of digestive enzymes, necrosis, immune infiltration, and pain. Repeated incidence of pancreatitis is an important risk factor for pancreatic cancer. Legumain, a lysosomal cysteine protease, has been linked to inflammatory diseases such as atherosclerosis, stroke, and cancer. Until now, legumain activation has not been studied during pancreatitis. We used a fluorescently quenched activity-based probe to assess legumain activation during caerulein-induced pancreatitis in mice. We detected activated legumain by ex ...
Source: Am J Physiol Gastroi... - August 10, 2016 Category: Gastroenterology Authors: Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Legumain is activated in macrophages during pancreatitis
Pancreatitis is an inflammatory disease of the pancreas characterized by dysregulated activity of digestive enzymes, necrosis, immune infiltration, and pain. Repeated incidence of pancreatitis is an important risk factor for pancreatic cancer. Legumain, a lysosomal cysteine protease, has been linked to inflammatory diseases such as atherosclerosis, stroke, and cancer. Until now, legumain activation has not been studied during pancreatitis. We used a fluorescently quenched activity-based probe to assess legumain activation during caerulein-induced pancreatitis in mice. We detected activated legumain by ex vivo imaging, conf...
Source: AJP: Gastrointestinal and Liver Physiology - September 8, 2016 Category: Gastroenterology Authors: Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Ha Tags: PANCREATIC PHYSIOLOGY/PATHOPHYSIOLOGY Source Type: research