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Ischemic stroke in patients with gliomas at The University of Texas-M.D. Anderson Cancer Center
Abstract Patients with gliomas are at risk of cerebrovascular accidents (CVA) with potential consequences on survival, function, and local tumor control. Our objective was to provide information about CVA in patients with gliomas and to estimate survival in this group. We reviewed all adult glioma patients with ischemic CVA at the University of Texas-M.D. Anderson Cancer Center from 2003 through 2014. We extracted demographic, clinical, imaging, treatment and outcome data. We used descriptive summary data and estimated or compared survival rates where appropriate. 60 of 6500 patients (0.1 %) with high-grade (HGG,...
Source: Journal of Neuro-Oncology - August 14, 2015 Category: Cancer & Oncology Source Type: research

Calcification in high grade gliomas treated with bevacizumab
Abstract Calcification is a rare phenomenon in high grade glioma (HGG). CT scans are sensitive to mineralization but used infrequently for tumor assessment in the MRI era. The presence of calcification can be overlooked on routine MRI. Calcification may reflect chronicity and natural changes in the tumor or its milieu over time and may be accelerated by certain treatments. Calcification may have clinical significance which could signal potential risk for stroke or hemorrhage related to particular therapies; or it may be a positive prognostic factor for treatment response. The true incidence and relevance of calcif...
Source: Journal of Neuro-Oncology - May 5, 2015 Category: Cancer & Oncology Source Type: research

Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia
AbstractSurgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Unfortunately, these processes are also associated with tumorigenic side-effects. An increasing amount of evidence indicates that the response to a surgery-related brain injury is hijacked by residual glioma cells and participates in the local regeneration of tumor ti...
Source: Journal of Neuro-Oncology - May 17, 2017 Category: Cancer & Oncology Source Type: research

Features of diffuse gliomas that are misdiagnosed on initial neuroimaging: a case control study
ConclusionSeveral clinical and radiologic metrics are associated with diffuse gliomas that are missed or misdiagnosed on the initial neuroimaging study. Knowledge of these associations may aid in avoiding misinterpretation and accurately diagnosing such cases in clinical practice.
Source: Journal of Neuro-Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Contrast enhancing spots as a new pattern of late onset pseudoprogression in glioma patients
ConclusionWe hypothesize that the late onset phenomenon of NCES predominantly represents a form of radiation-induced vasculopathy that is different from early pseudoprogression and should be considered especially in younger patients with IDH-mutated glioma before initiation of new therapy.
Source: Journal of Neuro-Oncology - January 2, 2019 Category: Cancer & Oncology Source Type: research