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Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
CONCLUSION: These findings suggested that Sirt1 may regulate microglial activation and inflammation by targeting the Shh/Gli-1 signaling pathway following OGD/R injury. Schematic representation of Sirt1 regulating the microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury via mediation of Shh/Gli-1 signaling pathway.PMID:36725745 | DOI:10.1007/s11033-022-08167-6
Source: Mol Biol Cell - February 1, 2023 Category: Molecular Biology Authors: Hongyan Liao Jiagui Huang Jie Liu Huimin Zhu Yue Chen Xuemei Li Jun Wen Qin Yang Source Type: research

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity.
Abstract SUMMARYThe literature review presented here details recent research involving members of the poly(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of the family, the human enzyme PARP1 is the most extensively studied, resulting in a number of known biological and metabolic roles. This review is focused on the roles played by PARP enzymes in host-pathogen interactions and in diseases with an associated inflammatory response. In mammalian cells, several PARPs have specific roles in the antiviral response; this is perhaps best illustrated by PARP13, also termed the zinc finge...
Source: Mol Biol Cell - December 22, 2018 Category: Molecular Biology Authors: Brady PN, Goel A, Johnson MA Tags: Microbiol Mol Biol Rev Source Type: research