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Serum retinol-binding protein 4 in stroke patients: correlation with T helper 17/regulatory T cell imbalance and 3-year cognitive function decline
ConclusionSerum RBP4 is positively associated with a Th17/Treg cell imbalance and, more importantly, it is indicative of cognitive function decline within 3 years in stroke patients. Thus, early and timely interventions and physical rehabilitation are more necessary in stroke patients with high serum RBP4.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research

Corrigendum: Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
Source: Frontiers in Neurology - July 27, 2023 Category: Neurology Source Type: research

Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
ConclusionA fast and fully automatic method can be used for stroke subtype risk assessment and classification based on fundus photographs alone.
Source: Frontiers in Neurology - August 22, 2022 Category: Neurology Source Type: research

Effects of remote ischemic conditioning on sleep complaints in Parkinson's disease –rationale, design, and protocol for a randomized controlled study
ConclusionThis study is a prospective randomized controlled trial to determine the safety, feasibility, and potential efficacy of RIC for patients with Parkinson's disease associated with EDS.
Source: Frontiers in Neurology - July 25, 2022 Category: Neurology Source Type: research

Central Retinal Artery Occlusion: Current Practice, Awareness and Prehospital Delays in Switzerland
ConclusionsCRAO awareness of the general population and physician awareness about the treatment options as well as the non-standardized prehospital organization, seems to be the main reason for the prehospital delays and impedes treating CRAO patients. Educational efforts should be undertaken to improve awareness about CRAO.
Source: Frontiers in Neurology - May 23, 2022 Category: Neurology Source Type: research

Vascular Reactivity to Hypercapnia Is Impaired in the Cerebral and Retinal Vasculature in the Acute Phase After Experimental Subarachnoid Hemorrhage
Conclusion: This study provides a detailed temporal analysis of impaired cerebral vascular CO2 reactivity starting immediately after SAH and lasting up to 6 h. Importantly, the retinal vessels participate in these acute changes underscoring the promising role of the retina as a potential non-invasive screening tool after SAH. Further studies will be required to determine the correlation with functional outcomes.
Source: Frontiers in Neurology - January 13, 2022 Category: Neurology Source Type: research

Risk Stratification Tool for Ischemic Stroke: A Risk Assessment Model Based on Traditional Risk Factors Combined With White Matter Lesions and Retinal Vascular Caliber
Conclusion: The risk assessment model of ischemic stroke combined with Fazekas grade of WML and CRAE is superior to the traditional risk factor and the single-index model. This model is helpful for risk stratification of high-risk stroke patients.
Source: Frontiers in Neurology - August 4, 2021 Category: Neurology Source Type: research

Retinal Microvascular Changes in Subtypes of Ischemic Stroke
Conclusion: Retinal MVD0.5−1.0DD (>82.23 μm) might be associated with the AT stroke subtype; however, we need large-scale prospective studies in future to explore the underlying mechanism and causal explanation for this finding.
Source: Frontiers in Neurology - January 27, 2021 Category: Neurology Source Type: research

Who Should Rather Undergo Transesophageal Echocardiography to Determine Stroke Etiology: Young or Elderly Stroke Patients?
Conclusions: TEE was highly valuable for determining stroke etiology and influenced individual secondary prevention based on available treatment guidelines and expert opinion in most cases. In young patients the impact of TEE was limited to the detection of septal anomalies. By contrast, in older patients TEE detected high numbers of complex aortic atheroma and potential indicators of paroxysmal atrial fibrillation.
Source: Frontiers in Neurology - December 18, 2020 Category: Neurology Source Type: research

Variations in the Presence of Carotid Intraplaque Hemorrhage Across Age Categories: What Age Groups Are Most Likely to Benefit From Plaque Imaging?
Although carotid artery intraplaque hemorrhage (IPH) is a known risk-factor for cerebral ischemic events in patients of advanced age, its prevalence in younger cohorts is less certain. The purpose of this study was to assess the prevalence of carotid artery IPH across the age spectrum. A retrospective review was completed of all adult patients from our institution who underwent neck MRA with high-resolution carotid plaque imaging between 2017 and 2020. The mean ages of patients with and without IPH were calculated. The prevalence of IPH was compared between patients that were categorized into age groups. Patients with and ...
Source: Frontiers in Neurology - December 14, 2020 Category: Neurology Source Type: research

The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review
Conclusions: Changes in retinal microvasculature identified using OCTA are associated with monogenic SVD and different stages of AD, but data are limited and partly confounded by methodological differences. Larger studies with risk factors adjustment and more consistent OCTA methods are needed to fully exploit this technology.PROSPERO registration number: CRD42020166929.
Source: Frontiers in Neurology - September 9, 2020 Category: Neurology Source Type: research

Structural and Microvascular Changes in the Macular Are Associated With Severity of White Matter Lesions
Conclusions: Microvascular impairment and neuro-axonal damage are associated with the disease cascade in WMH. We have shown that RPC and DCP densities are significantly affected, and these impairments are associated with the severity of the disease and cognitive function. OCT-A could be a useful tool in quantifying the retinal capillary densities in WMH.
Source: Frontiers in Neurology - June 29, 2020 Category: Neurology Source Type: research

Retinal Vascular Pathology in a Rat Model of Cerebral Small Vessel Disease
Conclusions: These results indicate that SVD also occurs in the retinal microvasculature of SHRSP and the prediction of cerebral erythrocyte thrombi and CAA might be possible using retinal biomarkers. This underlines the important role of the investigation of the retina in the early diagnosis of CSVD.
Source: Frontiers in Neurology - June 29, 2020 Category: Neurology Source Type: research

Retinal Changes After Posterior Cerebral Artery Infarctions Display Different Patterns of the Nasal und Temporal Sector in a Case Series
Conclusion: The dynamics of OCT and mfVEP outcomes for degeneration and recovery after PCA infarction differ between the nasal and temporal retinal sector. We postulate that retinal sectors may differ in their temporal pattern of TRD over time after retrogeniculate cerebral infarction.
Source: Frontiers in Neurology - June 4, 2020 Category: Neurology Source Type: research

Prediction for the Total MRI Burden of Cerebral Small Vessel Disease With Retinal Microvascular Abnormalities in Ischemic Stroke/TIA Patients
Conclusions: These results suggest that retinal microvascular abnormalities have predictive value for severe total cSVD burden in ischemic stroke/TIA patients.
Source: Frontiers in Neurology - April 15, 2020 Category: Neurology Source Type: research

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