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The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats
Exp Gerontol. 2021 Feb 17;147:111286. doi: 10.1016/j.exger.2021.111286. Online ahead of print.ABSTRACTBrain-derived neurotrophic factor (BDNF) is known to have neuroprotective effects on multiple neurovascular diseases especially poststroke recovery. On the other hand, BDNF reported to increase blood pressure (BP) which is one of the major risk factors for stroke onset. To clarify the conflicting effects on stroke onset, we examined the expression of endogenous BDNF in relation to stroke onset. In addition, we explored the effect of exogenous central BDNF against stroke onset and all-cause mortality as the primary endpoint...
Source: Experimental Gerontology - February 20, 2021 Category: Geriatrics Authors: Yu Hasegawa Yushin Takemoto Kenyu Hayashi Koki Kameno Shokei Kim-Mitsuyama Source Type: research

The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats.
Abstract Brain-derived neurotrophic factor (BDNF) is known to have neuroprotective effects on multiple neurovascular diseases especially poststroke recovery. On the other hand, BDNF reported to increase blood pressure (BP) which is one of the major risk factor for stroke onset. To clarify the conflicting effects on stroke onset, we examined the expression of endogenous BDNF in relation to stroke onset. In addition, we explored the effect of exogenous central BDNF against stroke onset and all-cause mortality as the primary endpoint and BP as the secondary object in hypertensive rats with high-salt diet. In experime...
Source: Experimental Gerontology - February 17, 2021 Category: Geriatrics Authors: Hasegawa Y, Takemoto Y, Hayashi K, Kameno K, Kim-Mitsuyama S Tags: Exp Gerontol Source Type: research