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Iron Chelation Therapy to Prevent Post-Stroke Cognitive Impairments: Role of Diabetes and Sex
Am J Physiol Heart Circ Physiol. 2023 Jan 6. doi: 10.1152/ajpheart.00004.2023. Online ahead of print.NO ABSTRACTPMID:36607799 | DOI:10.1152/ajpheart.00004.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 6, 2023 Category: Physiology Authors: Siva S V P Sakamuri Venkata N Sure Prasad V G Katakam Source Type: research

Deferoxamine Prevents Post-Stroke Memory Impairment in Female Diabetic Rats: Potential Links to Hemorrhagic Transformation and Ferroptosis
Am J Physiol Heart Circ Physiol. 2022 Dec 23. doi: 10.1152/ajpheart.00490.2022. Online ahead of print.ABSTRACTDiabetes increases the risk of post-stroke cognitive impairment (PSCI). Greater hemorrhagic transformation (HT) after stroke is associated with vasoregression and cognitive decline in male diabetic rats. Iron chelator deferoxamine (DFX) prevents vasoregression and improves outcomes. While diabetic female rats develop greater HT, its impact on post-stroke cerebrovascularization and cognitive outcomes remained unknown. We hypothesized that diabetes mediates pathological neovascularization, and DFX attenuates post-str...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 23, 2022 Category: Physiology Authors: Weiguo Li Yasir Abdul Raghavendar Chandran Sarah Jamil Rebecca A Ward Mohammed Abdelsaid Guangkuo Dong Susan C Fagan Adviye Ergul Source Type: research

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