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Cholestyramine resin administration alleviated cerebral ischemic injury in obese mice by improving gut dysbiosis and modulating the bile acid profile
In conclusion, Obesity induces gut dysbiosis, worsens stroke outcomes, and perturbs the BA profile. The dysbiotic microbiome is an important linkage between obesity and stroke. CR confers metabolic benefits and neuroprotective effects in obesity, perhaps by modulating gut microbial composition and BA metabolism.PMID:36179877 | DOI:10.1016/j.expneurol.2022.114234
Source: Experimental Neurology - September 30, 2022 Category: Neurology Authors: Jianhai Liang Mingsi Zhang Huidi Wang Yueran Ren Qiheng Wu Ranshi Huang Jiahui Xie Jia Yin Jiajia Zhu Source Type: research

Formic acid induces hypertension-related hemorrhage in hSSAO < sup > TG < /sup > in mice and human
In this study, 42 hemorrhagic patients with hypertension and hyperlipidemia and 42 age-matched healthy controls were enrolled. The contents of serum semicarbazide-sensitive amine oxidase (SSAO) and formic acid (FC, FC is a final product of SSAO through the oxidation of endogenous formaldehyde, which results from the enzymatic oxidative deamination of the SSAO substrate, methylamine) were examined in the patients after stroke. Hemorrhagic areas were quantified by computer tomography. In the animal study, hemorrhagic degree was assessed by hemotoxylin & eosin or tissue hemoglobin kits. The relationship between FC and blo...
Source: Experimental Neurology - August 21, 2022 Category: Neurology Authors: Ya-Lan Di Yan Yu Sheng-Jie Zhao Nayan Huang Xue-Chao Fei Dan-Dan Yao Li Ai Ji-Hui Lyu Rong-Qiao He Jian-Jun Li Zhi-Qian Tong Source Type: research

Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats.
CONCLUSIONS: T2DM-MSC-Exo treatment for stroke in T2DM rats promotes neurorestorative effects and improves functional outcome. Down regulation of miR-9 expression and increasing its target ABCA1 pathway may contribute partially to T2DM-MSC-Exo treatment induced white matter remodeling and anti-inflammatory responses. PMID: 32889008 [PubMed - as supplied by publisher]
Source: Experimental Neurology - August 31, 2020 Category: Neurology Authors: Venkat P, Zacharek A, Landschoot-Ward J, Wang F, Culmone L, Chen Z, Chopp M, Chen J Tags: Exp Neurol Source Type: research