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Source: IUBMB Life
Nutrition: High Fat
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Total 2 results found since Jan 2013.
Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn
AbstractAtherosclerosis, a chronic inflammatory disease that often leads to myocardial infarction and stroke, is mainly caused by lipid accumulation. Eukaryotic initiation factor 6 (Eif6) is a rate-limiting factor in protein translation of transcription factors necessary for lipogenesis. To determine whetherEif6 affects atherosclerosis,Eif6+/ − mice were crossed intoApoe −/− background.Apoe −/−/Eif6+/− mice on high fat diet showed significant reduction in atherosclerotic lesions and necrotic core content in aortic root sections in comparison withApoe −/− mice. RNA-Seq was used to investigate the effect of E...
Source: IUBMB Life - December 6, 2022 Category: Research Authors: Yang Chen,
Zhenzhen Wang,
Xuemei Xian,
Yun Zhuang,
Jiajia Chang,
Xiaoqiang Zhan,
Xufeng Han,
Quangang Chen,
Zhangping Yang,
Renjin Chen Tags: RESEARCH ARTICLE Source Type: research
