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miR-9 Upregulation Integrates Post-ischemic Neuronal Survival and Regeneration In Vitro.
Abstract The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesis served as a premise to experimentally uncover the functional role of miR-9 in post-ischemic neuronal survival and regeneration. The oxygen-glucose deprivation (OGD) in SH-SY5Y cells significantly reduced miR-9 expression, while miR-9 mimic transfection enhanced post-ischemic neuronal cell v...
Source: Cellular and Molecular Neurobiology - December 11, 2018 Category: Cytology Authors: Nampoothiri SS, Rajanikant GK Tags: Cell Mol Neurobiol Source Type: research