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Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke
In this study, using transient ischemic stroke models, we first demonstrated that neuron-specific overexpression of Xbp1s improved outcome, and pharmacologically boosting O-GlcNAcylation with thiamet-G reversed worse outcome observed in neuron-specific Xbp1 knockout mice. We further showed that thiamet-G treatment improved long-term functional recovery in both young and aged animals after transient ischemic stroke. Mechanistically, using an analytic approach developed here, we discovered that availability of UDP-GlcNAc was compromised in the aged brain, which may constitute a novel mechanism responsible for the impaired O-...
Source: Experimental Neurology - February 18, 2021 Category: Neurology Authors: Zhuoran Wang Xuan Li Ivan Spasojevic Liping Lu Yuntian Shen Xingguang Qu Ulrike Hoffmann David S Warner Wulf Paschen Huaxin Sheng Wei Yang Source Type: research

Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.
In this study, using transient ischemic stroke models, we first demonstrated that neuron-specific overexpression of Xbp1s improved outcome, and pharmacologically boosting O-GlcNAcylation with thiamet-G reversed worse outcome observed in neuron-specific Xbp1 knockout mice. We further showed that thiamet-G treatment improved long-term functional recovery in both young and aged animals after transient ischemic stroke. Mechanistically, using an analytic approach developed here, we discovered that availability of UDP-GlcNAc was compromised in the aged brain, which may constitute a novel mechanism responsible for the impaired O-...
Source: Experimental Neurology - February 15, 2021 Category: Neurology Authors: Wang Z, Li X, Spasojevic I, Lu L, Shen Y, Qu X, Hoffmann U, Warner DS, Paschen W, Sheng H, Yang W Tags: Exp Neurol Source Type: research

Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats.
In conclusion, OH-F and GlcN-F lead to a reduction of cellular damage and inflammation after stroke, rendering these compounds attractive therapeutics for stroke. PMID: 25625851 [PubMed - as supplied by publisher]
Source: Experimental Neurology - January 24, 2015 Category: Neurology Authors: Fluri F, Grünstein D, Cam E, Ungethuem U, Hatz F, Schäfer J, Samnick S, Israel I, Kleinschnitz C, Orts-Gil G, Moch H, Zeis T, Schaeren-Wiemers N, Seeberger P Tags: Exp Neurol Source Type: research