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Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs
Biomed Pharmacother. 2022 Feb 12;148:112719. doi: 10.1016/j.biopha.2022.112719. Online ahead of print.ABSTRACTNeuroprotective and neurorestorative therapy represent two major drug intervention strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation, angiogenesis, and neurogenesis are the main pathological processes that underlie acute and chronic ischemic brain injury. Furthermore, their intimate interactions mediate blood-brain barrier permeability, increase neurovascular unit structural damage as well as a hemorrhagic transformation during ischemic stroke. We aimed to review the current unde...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 15, 2022 Category: Drugs & Pharmacology Authors: Ting Zhu Lei Wang Li-Ping Wang Qi Wan Source Type: research

Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BK < sub > Ca < /sub > channels in endothelial cells
Biomed Pharmacother. 2021 Aug 12;142:112039. doi: 10.1016/j.biopha.2021.112039. Online ahead of print.ABSTRACTMitochondrial potassium channels have been implicated in cytoprotective mechanisms. Activation of the mitochondrial large-conductance Ca2+-regulated potassium (mitoBKCa) channel is important for protecting brain tissue against stroke damage as well as heart tissue against ischemia damage. In this paper, we examine the effect of the natural flavonoid quercetin as an activator of the mitoBKCa channel. Quercetin has a beneficial effect on many processes in the human body and interacts with many receptors and signaling...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 15, 2021 Category: Drugs & Pharmacology Authors: Rafa ł Paweł Kampa Aleksandra S ęk Adam Szewczyk Piotr Bednarczyk Source Type: research

Myricetin against myocardial injury in rat heat stroke model.
CONCLUSIONS: Our results indicate that myricetin diminishes myocardial injury as well as lethality in heat stroke by up-regulating HSP-72 and show promise as a novel prevention therapeutic for heat stroke. PMID: 32371315 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2020 Category: Drugs & Pharmacology Authors: Lin X, Lin CH, Liu R, Li C, Jiao S, Yi X, Walker MJ, Xu XM, Zhao T, Huang PC, Sun G Tags: Biomed Pharmacother Source Type: research