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Specialty: Urology & Nephrology
Source: International Urology and Nephrology
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Total 2 results found since Jan 2013.
The role of gut-dependent molecule trimethylamine N-oxide as a novel target for the treatment of chronic kidney disease
AbstractTrimethylamine N-oxide (TMAO) is an intestinal uremic toxin molecule mainly excreted by the kidney. Therefore, the plasma TMAO concentration is significantly increased in chronic kidney disease (CKD) patients, and plasma TMAO can be cleared by dialysis. Furthermore, TMAO damage the kidney mainly through three mechanisms: oxidative stress, inflammation and endoplasmic reticulum stress. Clinical experiments have indicated that higher TMAO levels are strongly related to the elevated incidence and mortality of cardiovascular (CV) events in CKD patients. Moreover, experimental data have shown that high levels of TMAO di...
Source: International Urology and Nephrology - February 16, 2023 Category: Urology & Nephrology Source Type: research
