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Source: Cell Host and Microbe
Procedure: Transplants
Nutrition: Diets
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Total 7 results found since Jan 2013.
Gut microbes impact stroke severity via the trimethylamine N-oxide pathway
Cell Host Microbe. 2021 Jun 10:S1931-3128(21)00230-4. doi: 10.1016/j.chom.2021.05.002. Online ahead of print.ABSTRACTClinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietary choline and TMAO generation, directly impact cerebral infarct size and adverse outcomes following stroke. Fecal microbial transplantation from low- versus high-TMAO-producing human subjects into germ-free mice s...
Source: Cell Host and Microbe - June 17, 2021 Category: Microbiology Authors: Weifei Zhu Kymberleigh A Romano Lin Li Jennifer A Buffa Naseer Sangwan Prem Prakash Aaron N Tittle Xinmin S Li Xiaoming Fu Charlie Androjna Anthony J DiDonato Kimberly Brinson Bruce D Trapp Michael A Fischbach Federico E Rey Adeline M Hajjar Joseph A DiDo Source Type: research
