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Source: Molecular Neurobiology
Nutrition: Cobalt
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Total 1 results found since Jan 2013.
Neuroprotective Effects of a Cardioplegic Combination (Adenosine, Lidocaine, and Magnesium) in an Ischemic Stroke Model
We examined the effects of low-dose ALM on ischemic stroke in cell and animal models. Cobalt chloride (CoCl2) –treated SH-SY5Y cells were used as a surrogate model to mimic oxygen–glucose deprivation conditions. The cells were incubated with different dilutions of ALM authentic solution (1.0 mM adenosine, 2.0 mM lidocaine, and5 mM MgSO4 in Earle’s balanced salt solution). At a concentration of 2.5%, ALM significantly reduced CoCl2-induced cell loss. This protective effect persisted even when ALM was administered 1 h after the insult. We used transient middle cerebral artery occlusion to investigate the therapeuti...
Source: Molecular Neurobiology - October 1, 2022 Category: Neurology Source Type: research
