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Specialty: Allergy & Immunology
Source: Journal of Immunology
Nutrition: Chloride
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Total 2 results found since Jan 2013.
Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation
In this study, we demonstrated that VRACs comprising LRRC8A and LRRC8E (LRRC8A/E-containing VRACs), specialized in cGAMP transport, can be opened by a protein component present in serum under resting condition. Serum depletion ablated the tonic activity of LRRC8A/E-containing VRACs, decreasing cGAMP transport in various human and murine cells. Also, heating or proteinase K treatment abolished the ability of serum to activate VRAC. Genetic analyses revealed a crucial role for cGAMP synthase (cGAS) in serum/TNF-promoted VRAC activation. Notably, the presence of cGAS on the plasma membrane, rather than its DNA-binding or enzy...
Source: Journal of Immunology - April 8, 2021 Category: Allergy & Immunology Authors: Xia Chen Li Wang Limin Cao Tiantian Li Zhihong Li Yumeng Sun Jinqiu Ding Chun Zhou Yadong Xie Nan Yue Jing Nan Xin-Ming Jia Chao Peng Huabin Li Jinbo Yang Hui Xiao Source Type: research
