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Motor deficit in the mouse ferric chloride-induced distal middle cerebral artery occlusion model of stroke.
In this study, we reproduced the recently developed model and expanded its characterization by thorough evaluation of blood supply, cerebral infarction, and motor function in adult male and female mice up to 14 days after stroke. Our observations indicate near complete interruption of blood flow in the distal MCA shortly after application of 20% ferric chloride over the artery through a cranial window, which remained occluded for at least 4 hours. As expected, infarction of the brain tissue, documented by TTC and hematoxylin stains, was restricted to the cerebral cortex. We also systematically evaluated motor impairment ...
Source: Behavioural Brain Research - December 4, 2019 Category: Neurology Authors: Syeara N, Alamri FF, Jayaraman S, Lee P, Karamyan ST, Arumugam TV, Karamyan VT Tags: Behav Brain Res Source Type: research

Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus.
Abstract Existing evidence from clinical and animal experiments all indicated that fluoxetine, selective serotonin-reuptake inhibitor (SSRI) and anti-depressant drug, has neuroprotection and improve functional outcomes after stroke. Endoplasmic reticulum stress (ERS) inducing apoptosis after cerebral ischemia reperfusion injury was demonstrated in our previous. This trial was examined whether fluoxetine mitigates ERS-induced neuron apoptosis. Male sprague-dawley rats of cerebral ischemia reperfusion injury was produced via middle cerebral artery occlusion (MCAO) strategy, with ischemia for 90 min and reperfusion...
Source: Behavioural Brain Research - May 15, 2019 Category: Neurology Authors: Xu F, Zhang G, Yin J, Zhang Q, Ge MY, Peng L, Wang S, Li Y Tags: Behav Brain Res Source Type: research