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A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber
We present a novel rat model of focal infarct restricted to the middle cerebral artery territory using a radiopaque hydrogel microfiber positioned under fluoroscopic guidance. By comparing the use of stem cell-containing versus non-containing fibers in this stroke model, it would be possible to determine the efficacy of "pure" cell transplantation in treating stroke.PMID:36867349 | DOI:10.1007/s12975-023-01144-6
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Teppei Komatsu Hiroki Ohta Naoki Takakura Junichi Hata Tomomichi Kitagawa Yuta Kurashina Hiroaki Onoe Hirotaka James Okano Yasuyuki Iguchi Source Type: research

Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats
CONCLUSIONS: Our results demonstrated that infarct-preconditioned exosomes promoted neurological recovery after stroke by enhancing vascular endothelial remodeling, suggested that infarct-preconditioned exosomes could be a novel way to alleviate brain damage following a stroke.PMID:35902882 | DOI:10.1186/s13287-022-03083-9
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Yi-Chao Ye Zhe-Han Chang Peng Wang You-Wei Wang Jun Liang Chong Chen Jing-Jing Wang Hong-Tao Sun Yi Wang Xiao-Hong Li Source Type: research