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Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function.
Abstract ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the pathophysiology of various neurological diseases such as epilepsy, Alzheimer's disease and stroke. GABA transporters (GATs) facilitate the termination of GABAergic signaling by transporting GABA together with sodium and chloride from the synaptic cleft into presynaptic neurons and surrounding glial cells. Four different GATs have been identified that all belong to the solute carrier 6 (SLC6) transporter family: GAT1-3 (SLC6A1, SLC6A...
Source: Neuropharmacology - May 16, 2019 Category: Drugs & Pharmacology Authors: Kickinger S, Hellsberg E, BenteFrølund, Schousboe A, Ecker GF, Wellendorph P Tags: Neuropharmacology Source Type: research